U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ORF59 ORF59 [ Human gammaherpesvirus 8 ]

Gene ID: 4961492, updated on 18-Aug-2023

Summary

Go to the top of the page Help
Gene symbol
ORF59
Gene description
ORF59
Locus tag
HHV8GK18_gp70
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_009333.1 (94577..96845, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene vIRF-3 Neighboring gene vIRF-2 Neighboring gene ORF58 Neighboring gene ORF60 Neighboring gene ORF61 Neighboring gene ORF62 Neighboring gene ORF63 Neighboring gene ORF64 Neighboring gene ORF67A Neighboring gene ORF65 Neighboring gene ORF66 Neighboring gene ORF67 Neighboring gene ORF68 Neighboring gene ORF69

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Kaposi's Sarcoma-Associated Herpesvirus Processivity Factor, ORF59, Binds to Canonical and Linker Histones, and Its Carboxy Terminus Is Dispensable for Viral DNA Synthesis. Gutierrez IV, et al. J Virol, 2021 Feb 24. PMID 33361421, Free PMC Article
  2. Kaposi's Sarcoma-Associated Herpesvirus Deregulates Host Cellular Replication during Lytic Reactivation by Disrupting the MCM Complex through ORF59. Strahan R, et al. J Virol, 2018 Nov 15. PMID 30158293, Free PMC Article
  3. KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation. Strahan RC, et al. PLoS Pathog, 2017 Jul. PMID 28678843, Free PMC Article
  4. Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt. McDowell ME, et al. J Virol, 2013 Jul. PMID 23678174, Free PMC Article
  5. The KSHV ORF20 Protein Interacts with the Viral Processivity Factor ORF59 and Promotes Viral Reactivation. Hoffman D, et al. Microbiol Spectr, 2021 Sep 3. PMID 34106579, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The KSHV ORF20 Protein Interacts with the Viral Processivity Factor ORF59 and Promotes Viral Reactivation.
    Title: The KSHV ORF20 Protein Interacts with the Viral Processivity Factor ORF59 and Promotes Viral Reactivation.
  2. Kaposi's Sarcoma-Associated Herpesvirus Processivity Factor, ORF59, Binds to Canonical and Linker Histones, and Its Carboxy Terminus Is Dispensable for Viral DNA Synthesis.
    Title: Kaposi's Sarcoma-Associated Herpesvirus Processivity Factor, ORF59, Binds to Canonical and Linker Histones, and Its Carboxy Terminus Is Dispensable for Viral DNA Synthesis.
  3. In this report, the authors elucidated an important role of ORF59 in manipulating the cellular environment conducive for viral DNA replication by deregulating the normal functions of the host Minichromosome maintenance (MCM) proteins. ORF59 binds to specific MCMs and sequesters them away from replication origins in order to sabotage cellular DNA replication.
    Title: Kaposi's Sarcoma-Associated Herpesvirus Deregulates Host Cellular Replication during Lytic Reactivation by Disrupting the MCM Complex through ORF59.
  4. ORF59 modulates histone-modifying enzymes to alter the chromatin structure during lytic reactivation.
    Title: KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation.
  5. The viral processivity factor of KSHV (PF-8) directly interacted with PARP-1 and was sufficient and necessary to degrade PARP-1 protein in a proteasome-dependent manner.
    Title: Downregulation of Poly(ADP-Ribose) Polymerase 1 by a Viral Processivity Factor Facilitates Lytic Replication of Gammaherpesvirus.
  6. Processivity factor 8 (PF-8) of Kaposi's sarcoma-associated herpesvirus was identified as interacting with Ku70 and Ku86, and the interaction was dependent on DNA double-strand breaks and DNA.
    Title: Lytic infection of Kaposi's sarcoma-associated herpesvirus induces DNA double-strand breaks and impairs non-homologous end joining.
  7. Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt.
    Title: Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt.
  8. A transient-transfection chromatin immunoprecipitation assay demonstrated that the interaction of ORF59 with oriLyt is dependent on binding with K-Rta and that ORF59 fails to bind to oriLyt in the absence of K-Rta.
    Title: Interaction of Kaposi's sarcoma-associated herpesvirus ORF59 with oriLyt is dependent on binding with K-Rta.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

regulatory

  • Loc: c94589-94584 regulatory_class = polyA_signal_sequence

General protein information

Go to the top of the page Help
Preferred Names
ORF59
YP_001129416.1
  • herpesvirus core gene UL42 family

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    94577..96845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129416.1 ORF59 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129416.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HID2
    UniProtKB/TrEMBL
    A0A7D3QFT6, O12655, P88950, Q2HR69, Q77ZG5
    Conserved Domains (1) summary
    pfam04929
    Location:6 → 396
    Herpes_DNAp_acc; Herpes DNA replication accessory factor
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.