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HHV8GK18_gp80 ORF71 [ Human gammaherpesvirus 8 ]

Gene ID: 4961494, updated on 20-Nov-2023

Summary

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Gene symbol
HHV8GK18_gp80
Gene description
ORF71
Locus tag
HHV8GK18_gp80
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (122337..122959, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene ORF72 Neighboring gene ORF73 Neighboring gene K14 Neighboring gene ORF74 Neighboring gene ORF75 Neighboring gene K15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo. Ballon G, et al. PLoS Pathog, 2015 Jan. PMID 25607954, Free PMC Article
  2. Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation. Othman Z, et al. RNA, 2014 Nov. PMID 25246653, Free PMC Article
  3. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. Punj V, et al. PLoS One, 2012. PMID 22624040, Free PMC Article
  4. vFLIP from KSHV inhibits anoikis of primary endothelial cells. Efklidou S, et al. J Cell Sci, 2008 Feb 15. PMID 18211958
  5. Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators. Cloutier N, et al. Eur J Immunol, 2007 Oct. PMID 17899551

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggests that viral FLIP neutralizes and compensates for cellular FLIP deletion, efficiently counteracting host cell death induction and facilitating further propagation in the host organism.
    Title: Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo.
  2. In conclusion, the spindle cell morphology should be induced by RelA activation (p-RelA S468) by IKKepsilon upregulation in human herpesvirus 8 vFLIP-expressing EA hy926 cells.
    Title: vFLIP upregulates IKKε, leading to spindle morphology formation through RelA activation.
  3. vFLIP alone induced expression of the NFkB responsive genes ICAM1 and TNFalpha, inclusion of RTA decreased vFLIP induced ICAM1 and TNFalpha expression.
    Title: KSHV RTA abolishes NFκB responsive gene expression during lytic reactivation by targeting vFLIP for degradation via the proteasome.
  4. IKKgamma is a parallel coiled-coil whose response to binding of vFLIP or IKKbeta is localized twisting.
    Title: Probing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR Spectroscopy.
  5. vFlip is capable of inducing vascular abnormalities and changes in host microenvironment with important implications for understanding the pathogenesis and treating KSHV-associated disease.
    Title: Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo.
  6. Study showed that a 252-nt fragment directly upstream of vFLIP, within a coding region, directs translation; its RNA structure was analyzed and showed that internal ribosomal entry site (IRES) activity requires the presence of eIF4A and an intact eIF4G; and unusually for an IRES, eIF4E is part of the complex assembled onto the vFLIP IRES to direct translation.
    Title: Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation.
  7. Kaposi's sarcoma-associated herpesvirus oncoprotein K13 upregulated the expression of NF-kappaB subunit RelB and blocked the anti-IgM-induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis.
    Title: Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation.
  8. K13 activates the RANTES/CCL5 promoter through the NF-kappaB pathway.
    Title: A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma.
  9. These findings highlight the role of Kaposi's sarcoma herpesvirus vFLIP in the activation of STAT1/STAT2 and STAT-responsive cellular genes in endothelial cells.
    Title: Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells.
  10. K13 is a key determinant of A20 expression in KSHV-infected cells, and A20 is a key negative regulator of K13-induced NF-kappaB activity
    Title: A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: c122342-122337 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
K13
Names
ORF71
vFLIP
YP_001129429.1
  • contains two death effector domains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    122337..122959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129429.1 ORF71 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129429.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HEZ4
    UniProtKB/TrEMBL
    A0A0N9SMH2, A0A7D3QH15, A0A7D3UHQ6, P88961, Q76RF1, Q77Q37
    Conserved Domains (2) summary
    cd08775
    Location:92 → 170
    DED_Caspase-like_r2; Death effector domain, repeat 2, of initator caspase-like proteins
    cd08776
    Location:3 → 64
    DED_Caspase-like_r1; Death effector domain, repeat 1, of initator caspase-like proteins
Nucleotide Protein
Heading Accession and Version

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