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vIRF-4 vIRF-4 [ Human gammaherpesvirus 8 ]

Gene ID: 4961495, updated on 18-Aug-2023

Summary

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Gene symbol
vIRF-4
Gene description
vIRF-4
Locus tag
HHV8GK18_gp63
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (86106..89172, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF56 Neighboring gene ORF57 Neighboring gene K9 Neighboring gene vIRF-3 Neighboring gene vIRF-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication. Lee HR, et al. J Virol, 2014 Feb. PMID 24335298, Free PMC Article
  2. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling. Heinzelmann K, et al. J Virol, 2010 Dec. PMID 20861242, Free PMC Article
  3. Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters. Xi X, et al. J Virol, 2012 Jan. PMID 22090118, Free PMC Article
  4. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. Lee HR, et al. J Virol, 2009 Jul. PMID 19369353, Free PMC Article
  5. KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production. Hwang SW, et al. Biochem Biophys Res Commun, 2017 May 6. PMID 28342865, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KSHV-encoded viral IRF4 interacts with the host IRF7 and inhibits interferon-alpha production.
    Title: KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production.
  2. Kaposi's sarcoma-associated herpesvirus vIRF4 targets the beta-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing virus replication.
    Title: Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene.
  3. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication.
  4. vIRF4 and RTA cooperate to activate the vIRF4 promoter.
    Title: Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters.
  5. Our data suggest that vIRF4 is a potential antagonist of Notch/CBF1 signal transduction.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.
  6. vIRF4 expression reduces MDM2 ubiquitination, enhances p53 ubiquitination and, downregulates p53-mediated apoptosis.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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polyA_site

  • Loc: c86106

regulatory

  • Loc: c86130-86125 regulatory_class = polyA_signal_sequence
  • Loc: c89071-89066 regulatory_class = TATA_box
  • Loc: c89172-89167 regulatory_class = TATA_box

General protein information

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Preferred Names
vIRF-4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    86106..89172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129412.1 vIRF-4 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129412.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D0UZS2, Q2HR73
    UniProtKB/TrEMBL
    A0A0N9SCI5, A0A7D5JR94, A0A7D5KG32, F5H9D8
    Conserved Domains (1) summary
    PHA03247
    Location:232 → 634
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
Heading Accession and Version

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