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ORF57 ORF57 [ Human gammaherpesvirus 8 ]

Gene ID: 4961525, updated on 5-Oct-2023

Summary

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Gene symbol
ORF57
Gene description
ORF57
Locus tag
HHV8GK18_gp61
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (82169..83713)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF54 Neighboring gene ORF55 Neighboring gene ORF56 Neighboring gene K9 Neighboring gene vIRF-4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. Yuan F, et al. PLoS Pathog, 2018 Aug. PMID 30096191, Free PMC Article
  2. HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism. Sei E, et al. PLoS Pathog, 2015 Feb. PMID 25710169, Free PMC Article
  3. ORF57 overcomes the detrimental sequence bias of Kaposi's sarcoma-associated herpesvirus lytic genes. Vogt C, et al. J Virol, 2015 May. PMID 25694606, Free PMC Article
  4. Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization. Majerciak V, et al. J Virol, 2015 Mar. PMID 25568207, Free PMC Article
  5. Identification of the physiological gene targets of the essential lytic replicative Kaposi's sarcoma-associated herpesvirus ORF57 protein. Verma D, et al. J Virol, 2015 Feb. PMID 25410858, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways.
    Title: Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways.
  2. we report the important roles of GW182 and DDX6, but not Dicer, Ago2 and DCP1A, in PB formation, and that Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection reduces PB formation through several specific interactions with viral RNA-binding protein ORF57
    Title: KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.
  3. In both ORF57 and ICP27 the interaction sites for ALYREF and UIF partially overlap, suggestive of mutually exclusive binding. The data provide a map of the binding sites responsible for promoting herpes virus mRNA export, enabling future studies to accurately probe these interactions and reveal the functional consequences for UIF and ALYREF redundancy
    Title: Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF.
  4. First structure of KSHV ORF57-CTD and new insights into the understanding of ORF57 protein dimerization and stability, which would shed light on the potential design of novel therapeutics against KSHV infection and related diseases.
    Title: The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.
  5. data provide the first evidence that KSHV ORF57 plays a role in modulating PKR/eIF2alpha/SG axis and enhances virus production during virus lytic infection.
    Title: KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.
  6. Herein, the authors extend their previous research and provide evidence that ORF57 of human herpesvirus-8 interacts with CHTOP and CIP29, in contrast to POLDIP3.
    Title: Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29.
  7. These data suggest that ORF57 is involved in modulating host gene expression in addition to KSHV gene expression during lytic reactivation.
    Title: HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism.
  8. Authors speculate that binding of particular hnRNPs to human herpesvirus 8 lytic transcripts is the prerequisite for ORF57 to enhance their expression.
    Title: ORF57 overcomes the detrimental sequence bias of Kaposi's sarcoma-associated herpesvirus lytic genes.
  9. The C-terminal domain of ORF57contributes to homodimerization of ORF57 to prevent proteasome-mediated protein degradation.
    Title: Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.
  10. The eight genes identified to critically require ORF57 belong to both early and late lytic temporal classes, and seven are involved in DNA replication, virion assembly, or viral infectivity.
    Title: Identification of the physiological gene targets of the essential lytic replicative Kaposi's sarcoma-associated herpesvirus ORF57 protein.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: 83708-83713 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
ORF57
YP_001129410.1
  • herpesvirus core gene UL54 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    82169..83713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129410.1 ORF57 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129410.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O40938, Q2HR75
    UniProtKB/TrEMBL
    A0A0N9RWK7, A0A0N9SFL8, A0A7D3QGS1, D0UZS0
    Conserved Domains (1) summary
    pfam05459
    Location:236 → 453
    Herpes_UL69; Herpesvirus transcriptional regulator family
Nucleotide Protein
Heading Accession and Version

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