U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brca1 BRCA1, DNA repair associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 497672, updated on 23-Jun-2022

Summary

Official Symbol
Brca1provided by RGD
Official Full Name
BRCA1, DNA repair associatedprovided by RGD
Primary source
RGD:2218
See related
Ensembl:ENSRNOG00000020701 AllianceGenome:RGD:2218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BRCA-1
Summary
Enables chromatin binding activity. Involved in several processes, including positive regulation of protein import into nucleus; response to estradiol; and response to nutrient. Located in mitochondrial matrix. Biomarker of ductal carcinoma in situ. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); hereditary breast ovarian cancer syndrome; and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 83.6), Spleen (RPKM 54.5) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Brca1 in Genome Data Viewer
Location:
10q31
Exon count:
25
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86417441..86477762, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89394821..89455093, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene NBR1, autophagy cargo receptor Neighboring gene transmembrane protein 106A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to indole-3-methanol IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to indole-3-methanol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in chordate embryonic development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chordate embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in dosage compensation by inactivation of X chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dosage compensation by inactivation of X chromosome ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic G2/M transition checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of histone H3-K4 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone H3-K9 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of histone H3-K9 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of histone H3-K4 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H3-K9 acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of histone H3-K9 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H3-K9 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of histone H3-K9 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H4-K16 acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H4-K20 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of histone H4-K20 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in postreplication repair IEA
Inferred from Electronic Annotation
more info
 
involved_in postreplication repair ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression by genomic imprinting IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression by genomic imprinting ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-B complex IEA
Inferred from Electronic Annotation
more info
 
part_of BRCA1-B complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-BARD1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of BRCA1-BARD1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-BARD1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of BRCA1-C complex IEA
Inferred from Electronic Annotation
more info
 
part_of BRCA1-C complex ISO
Inferred from Sequence Orthology
more info
 
part_of DNA repair complex IEA
Inferred from Electronic Annotation
more info
 
part_of DNA repair complex ISO
Inferred from Sequence Orthology
more info
 
located_in XY body ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in lateral element IEA
Inferred from Electronic Annotation
more info
 
located_in lateral element ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
RING-type E3 ubiquitin transferase BRCA1
breast cancer 1, early onset
XP_008766314.1
XP_038942469.1
XP_038942470.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012514.2NP_036646.2  breast cancer type 1 susceptibility protein homolog

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    Related
    ENSRNOP00000028109.3, ENSRNOT00000028109.4
    Conserved Domains (4) summary
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17031800
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:15961692
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:343504
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    86417441..86477762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768092.3XP_008766314.1  breast cancer type 1 susceptibility protein homolog isoform X1

    See identical proteins and their annotated locations for XP_008766314.1

    UniProtKB/TrEMBL
    G3V8S5
    Conserved Domains (4) summary
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17031800
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:15961692
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:343504
    BRCT_assoc; Serine-rich domain associated with BRCT
  2. XM_039086541.1XP_038942469.1  breast cancer type 1 susceptibility protein homolog isoform X1

    Conserved Domains (4) summary
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17031800
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:15961692
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:343504
    BRCT_assoc; Serine-rich domain associated with BRCT
  3. XM_039086542.1XP_038942470.1  breast cancer type 1 susceptibility protein homolog isoform X2

    Conserved Domains (3) summary
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:343504
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl00038
    Location:15961676
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains