Si sucrase-isomaltase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Siprovided by RGD
Official Full Name: sucrase-isomaltaseprovided by RGD
Primary source: RGD:3675
See related: Ensembl:ENSRNOG00000031067 AllianceGenome:RGD:3675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SUCIMAL
Summary: Enables beta-fructofuranosidase activity and oligo-1,6-glucosidase activity. Involved in several processes, including response to fructose; response to sucrose; and response to vitamin A. Located in brush border and membrane raft. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 4.9) and Brain (RPKM 1.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q32

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (159804568..159884902, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (157505893..157586228, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (170220794..170301348, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression.
Title: Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression.
harmaline has an effect on rat intestinal brush border sucrase activity
Title: Effect of harmaline on rat intestinal brush border sucrase activity.
An abrupt jejunal induction of histone acetylation changes on the sucrase-isomaltase gene during this period may be concerned with the expression of the gene.
Title: Induction of histone acetylation on the sucrase-isomaltase gene in the postnatal rat jejunum.
The antidiabetic effect of tungstate is partly due to normalization of the activity of sucrase and SGLT1 in the brush-border membrane of enterocytes.
Title: Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats.
These results suggest that induction of the SI gene during the transition from the crypt to the villi is associated with changes in histone H3 modifications from methylation at lysine 9 to di-acetylation at lysine 9/14.
Title: Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in induction of the gene in the transition from the crypt to villus in the small intestine of rats.
Spermidine induction of sucrase-isomaltase in small intestine may be mediated by altered ornithine decarboxylase expression.
Title: Oral polyamine administration modifies the ontogeny of hexose transporter gene expression in the postnatal rat intestine.

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General gene information

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Markers

Si-s (e-PCR), detects polymorphism
- UniSTS:144403

RH94508 (e-PCR)
- UniSTS:119756

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-1,4-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-fructofuranosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables oligo-1,6-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables oligo-1,6-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables oligo-1,6-glucosidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sucrose alpha-glucosidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in sucrose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in sucrose catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sucrase-isomaltase, intestinal

Names: sucrase-isomaltase (alpha-glucosidase)

NP_001376155.1

EC 3.2.1.10

EC 3.2.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389226.1 → NP_001376155.1 sucrase-isomaltase, intestinal

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

F1M792

Related

ENSRNOP00000045106.5, ENSRNOT00000046681.5

Conserved Domains (6) summary

smart00018
Location:944 → 990

PD; P or trefoil or TFF domain

cd06602
Location:353 → 717

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:237 → 353

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:80 → 118

Trefoil; Trefoil (P-type) domain

pfam01055
Location:1204 → 1700

Glyco_hydro_31; Glycosyl hydrolases family 31

pfam16863
Location:135 → 244

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase