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Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497757, updated on 11-Apr-2024

Summary

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Official Symbol
Gucy1a1provided by RGD
Official Full Name
guanylate cyclase 1 soluble subunit alpha 1provided by RGD
Primary source
RGD:68436
See related
Ensembl:ENSRNOG00000012302 AllianceGenome:RGD:68436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SGC; Gucy1a3
Summary
Enables ion binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Involved in response to herbicide and response to organic cyclic compound. Part of guanylate cyclase complex, soluble. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 322.0), Thymus (RPKM 151.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (169716684..169780360, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (167418615..167482293, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (181045694..181103321, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 1 soluble subunit beta 1 Neighboring gene U6 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. Fernhoff NB, et al. J Biol Chem, 2012 Dec 14. PMID 23093402, Free PMC Article
  2. Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. Ibrahim M, et al. Biochemistry, 2010 Jun 15. PMID 20459051, Free PMC Article
  3. Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity. Zhou Z, et al. Arterioscler Thromb Vasc Biol, 2008 Oct. PMID 18635821, Free PMC Article
  4. Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis. Van Crombruggen K, et al. Eur J Pharmacol, 2008 Jan 28. PMID 18022154
  5. Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide. Almanza A, et al. J Neurophysiol, 2007 Feb. PMID 17182910

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FoxO4 controls sGCbeta transcription in vascular smooth muscle.
    Title: FoxO4 controls sGCβ transcription in vascular smooth muscle.
  2. GAPDH delivers heme to soluble guanylyl cyclase.
    Title: GAPDH delivers heme to soluble guanylyl cyclase.
  3. These studies identify MEK/ERK signaling as an important pathway by which TGFbeta regulates sGC expression in pulmonary artery smooth muscle cell.
    Title: Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling.
  4. Hence, SO2 exerted its vasodilatory effects at least partly by promoting disulfide-dependent dimerization of sGC and PKG, resulting in an activated sGC/cGMP/PKG pathway in blood vessels. These findings revealed a new mode of action and mechanisms by which SO2 regulated the vascular tone.
    Title: The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization.
  5. rhoA/rho-kinase and sGC/cGMP/PKG pathways play pivotal roles in cerebral vasospasm after subarachnoid hemorrhage.
    Title: Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage.
  6. The effect of glucagon-like peptide-2 on the expression of the alpha1, alpha2, and beta1 subunits of soluble guanylyl cyclase, was studied.
    Title: Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes.
  7. sGC undergoes a reductive nitrosylation reaction that is coupled to the S-nitrosation of sGC cysteines.
    Title: Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.
  8. Mechanisms of sGC activation are investigated by electronic absorption and resonance Raman spectroscopy, confirming that stoichiometrically bound 1-nitric oxide (1-NO) contains five-coordinate NO-heme cofactor.
    Title: Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.
  9. Soluble guanylate cyclase is activated by binding of carbon monoxide and YC-1.
    Title: Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.
  10. Based on these findings, we concluded that sGC immunoreactivity was specifically distributed in capillary pericytes
    Title: The expression of soluble guanylate cyclase in the vasculature of rat skeletal muscle.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to cytidylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables guanylate cyclase activity TAS
Traceable Author Statement
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables nitric oxide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in nitric oxide-cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within relaxation of vascular associated smooth muscle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to herbicide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of guanylate cyclase complex, soluble IDA
Inferred from Direct Assay
more info
 PubMed 
part_of guanylate cyclase complex, soluble ISO
Inferred from Sequence Orthology
more info
  
part_of guanylate cyclase complex, soluble TAS
Traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanylate cyclase soluble subunit alpha-1
Names
GCS-alpha-1
GCS-alpha-3
Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase)
guanylate cyclase 1 soluble subunit alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase soluble subunit alpha-3
soluble guanylate cyclase large subunit
NP_058786.2
XP_006232580.1
XP_008759329.1
XP_017446500.1
XP_063138383.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017090.2 → NP_058786.2  guanylate cyclase soluble subunit alpha-1

    See identical proteins and their annotated locations for NP_058786.2

    Status: PROVISIONAL

    Source sequence(s)
    BC085746
    UniProtKB/Swiss-Prot
    P19686
    UniProtKB/TrEMBL
    A6J5U0, F7ESJ1, Q5U330
    Related
    ENSRNOP00000017190.2, ENSRNOT00000017190.5
    Conserved Domains (4) summary
    smart00044
    Location:444 → 633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471 → 642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111 → 234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276 → 465
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    169716684..169780360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761107.4 → XP_008759329.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_008759329.1

    UniProtKB/Swiss-Prot
    P19686
    UniProtKB/TrEMBL
    A6J5U0, F7ESJ1, Q5U330
    Conserved Domains (4) summary
    smart00044
    Location:444 → 633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471 → 642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111 → 234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276 → 465
    HNOBA; Heme NO binding associated

  2. XM_006232518.5 → XP_006232580.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_006232580.1

    UniProtKB/Swiss-Prot
    P19686
    UniProtKB/TrEMBL
    A6J5U0, F7ESJ1, Q5U330
    Conserved Domains (4) summary
    smart00044
    Location:444 → 633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471 → 642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111 → 234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276 → 465
    HNOBA; Heme NO binding associated

  3. XM_063282313.1 → XP_063138383.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A6J5U0, F7ESJ1, Q5U330

  4. XM_017591011.3 → XP_017446500.1  guanylate cyclase soluble subunit alpha-1 isoform X1

    UniProtKB/Swiss-Prot
    P19686
    UniProtKB/TrEMBL
    A6J5U0, F7ESJ1, Q5U330
    Conserved Domains (4) summary
    smart00044
    Location:444 → 633
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:471 → 642
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:111 → 234
    HNOB; Haem-NO-binding
    pfam07701
    Location:276 → 465
    HNOBA; Heme NO binding associated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19686.1 GenPept UniProtKB/Swiss-Prot:P19686

Gene LinkOut

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