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Mief2 mitochondrial elongation factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497916, updated on 3-Apr-2024

Summary

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Official Symbol
Mief2provided by RGD
Official Full Name
mitochondrial elongation factor 2provided by RGD
Primary source
RGD:1560728
See related
Ensembl:ENSRNOG00000028208 AllianceGenome:RGD:1560728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Smcr7; RGD1560728
Summary
Predicted to be involved in several processes, including dynamin family protein polymerization involved in mitochondrial fission; positive regulation of mitochondrial fission; and positive regulation of protein targeting to membrane. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 49. Orthologous to human MIEF2 (mitochondrial elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 219.9), Heart (RPKM 118.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mief2 in Genome Data Viewer
Location:
10q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45907576..45913658)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45408055..45414144)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46969531..46975572)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene LLGL scribble cell polarity complex component 1 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene FLII, actin remodeling protein Neighboring gene DNA topoisomerase III alpha Neighboring gene SMCR8-C9orf72 complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies. Bartsakoulia M, et al. Hum Mol Genet, 2018 Apr 1. PMID 29361167, Free PMC Article
  2. MiD49 and MiD51, new components of the mitochondrial fission machinery. Palmer CS, et al. EMBO Rep, 2011 Jun. PMID 21508961, Free PMC Article
  3. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, et al. Cell Mol Life Sci, 2014 Jun. PMID 24442478, Free PMC Article
  4. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Koirala S, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23530241, Free PMC Article
  5. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, et al. Cell Signal, 2011 Oct. PMID 21683788

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
NOT involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial dynamics protein MID49
Names
Smith-Magenis syndrome chromosome region, candidate 7 homolog
mitochondrial dynamic protein MID49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398844.1 → NP_001385773.1  mitochondrial dynamics protein MID49

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6GLF2, A6HF53
    Related
    ENSRNOP00000023838.6, ENSRNOT00000023838.8
    Conserved Domains (1) summary
    pfam03281
    Location:392 → 439
    Mab-21; Mab-21 protein

  2. NM_001398845.1 → NP_001385774.1  mitochondrial dynamics protein MID49

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6GLF2, A6HF53
    Related
    ENSRNOP00000095022.1, ENSRNOT00000101878.1
    Conserved Domains (1) summary
    pfam03281
    Location:392 → 439
    Mab-21; Mab-21 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    45907576..45913658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087266.2 → XP_038943194.1  mitochondrial dynamics protein MID49 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLF2, A6HF53, D3ZS35
    Conserved Domains (1) summary
    pfam03281
    Location:392 → 439
    Mab-21; Mab-21 protein

  2. XM_039087269.2 → XP_038943197.1  mitochondrial dynamics protein MID49 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLF2, A6HF53, D3ZS35
    Conserved Domains (1) summary
    pfam03281
    Location:392 → 439
    Mab-21; Mab-21 protein
Nucleotide Protein Strain
Heading Accession and Version

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