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Rnf227 ring finger protein 227 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497935, updated on 13-Apr-2024

Summary

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Official Symbol
Rnf227provided by RGD
Official Full Name
ring finger protein 227provided by RGD
Primary source
RGD:1563441
See related
Ensembl:ENSRNOG00000021540 AllianceGenome:RGD:1563441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563441
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Orthologous to human RNF227 (ring finger protein 227). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 93.9), Testes (RPKM 10.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf227 in Genome Data Viewer
Location:
10q24
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54559862..54561823)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54061054..54063015)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55940533..55941205)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING finger protein 227

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126292.2 → NP_001119764.1  RING finger protein 227

    See identical proteins and their annotated locations for NP_001119764.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    B2BKZ7, B2BKZ9
    Related
    ENSRNOP00000012061.3, ENSRNOT00000012061.6
    Conserved Domains (3) summary
    cd00162
    Location:18 → 80
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam15451
    Location:117 → 187
    DUF4632; Domain of unknown function (DUF4632)
    cl17238
    Location:17 → 81
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54559862..54561823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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