U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spn88Ea Serpin 88Ea [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49804, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
Spn88Eaprovided by FlyBase
Official Full Name
Serpin 88Eaprovided by FlyBase
Primary source
FLYBASE:FBgn0028984
Locus tag
Dmel_CG18525
See related
AllianceGenome:FB:FBgn0028984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18525; Dmel\CG18525; sp5; Sp5; spn5; Spn5
Summary
Involved in several processes, including imaginal disc-derived wing expansion; negative regulation of Toll signaling pathway; and negative regulation of innate immune response. Located in extracellular region. Is expressed in several structures, including embryonic epidermis; embryonic/larval garland cell; embryonic/larval tracheal system; gut section; and ovary. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); lung disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINC1 (serpin family C member 1); and SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Spn88Ea in Genome Data Viewer
Location:
88E3-88E3; 3-56 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15203069..15206447, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11028791..11032169, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene uncharacterized protein Neighboring gene Serpin 88Eb Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The serpin Spn5 is essential for wing expansion in Drosophila melanogaster. Charron Y, et al. Int J Dev Biol, 2008. PMID 18956323
  2. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Colinet D, et al. Dev Comp Immunol, 2009 May. PMID 19109990
  3. A novel Drosophila serpin that inhibits serine proteases. Han J, et al. FEBS Lett, 2000 Feb 25. PMID 10692585
  4. Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila. Ohsawa S. Dev Growth Differ, 2019 Jun. PMID 30957223, Free PMC Article
  5. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study suggests that Spn5 secreted from normal epithelial cells acts as a component of the extracellular surveillance system that facilitates elimination of pre-malignant cells from epithelium.
    Title: Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila.
  2. Spn5 is a regulator of the Toll pathway and CHMP2B toxicity and the Toll pathway is a major signaling pathway misregulated by mutant CHMP2B in vivo.
    Title: Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.
  3. Spn5 is essential for wing expansion in Drosophila melanogaster.
    Title: The serpin Spn5 is essential for wing expansion in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived wing expansion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Toll receptor ligand protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serpin 88Ea
Names
CG18525-PA
CG18525-PB
Dm-serpin-88Ea
Spn88Ea-PA
Spn88Ea-PB
serine protease inhibitor 5
serpin
serpin 5
serpin5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15203069..15206447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176501.3 → NP_788678.1  serpin 88Ea, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788678.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U1I4, Q9VFC2
    Related
    FBpp0082596
    Conserved Domains (1) summary
    cd00172
    Location:39 → 419
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_080215.4 → NP_524954.2  serpin 88Ea, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524954.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U1I4, Q9VFC2
    Related
    FBpp0082595
    Conserved Domains (1) summary
    cd00172
    Location:39 → 419
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFC2.1 Q9VFC2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous