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Slc8b1 solute carrier family 8 member B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498185, updated on 30-Sep-2021

Summary

Official Symbol
Slc8b1provided by RGD
Official Full Name
solute carrier family 8 member B1provided by RGD
Primary source
RGD:1565818
See related
EnsemblRapid:ENSRNOG00000001383
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slc24a6
Expression
Biased expression in Spleen (RPKM 118.5), Kidney (RPKM 69.8) and 9 other tissues See more
Orthologs
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Genomic context

See Slc8b1 in Genome Data Viewer
Location:
12q16
Exon count:
16
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (36029759..36053087, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41566980..41590294, complement)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene IQ motif containing D Neighboring gene uncharacterized LOC120095848 Neighboring gene two pore segment channel 1 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in calcium export from the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium export from the mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium export from the mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cardiac muscle cell membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lymphocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lymphocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of store-operated calcium entry ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in integral component of mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial sodium/calcium exchanger protein
Names
Na(+)/K(+)/Ca(2+)-exchange protein 6
sodium/calcium exchanger protein, mitochondrial
sodium/potassium/calcium exchanger 6, mitochondrial
solute carrier family 24 (sodium/lithium/calcium exchanger), member 6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
solute carrier family 24 member 6
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017488.1NP_001017488.1  mitochondrial sodium/calcium exchanger protein precursor

    See identical proteins and their annotated locations for NP_001017488.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079350
    UniProtKB/Swiss-Prot
    Q6AXS0
    Related
    ENSRNOP00000034026.4, ENSRNOT00000038736.5
    Conserved Domains (1) summary
    PLN03151
    Location:63584
    PLN03151; cation/calcium exchanger; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    36029759..36053087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089705.1XP_038945633.1  mitochondrial sodium/calcium exchanger protein isoform X1

    Conserved Domains (1) summary
    PLN03151
    Location:63244
    PLN03151; cation/calcium exchanger; Provisional

RNA

  1. XR_005491667.1 RNA Sequence

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