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Spring1 SREBF pathway regulator in golgi 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498188, updated on 13-Apr-2024

Summary

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Official Symbol
Spring1provided by RGD
Official Full Name
SREBF pathway regulator in golgi 1provided by RGD
Primary source
RGD:1562310
See related
Ensembl:ENSRNOG00000001123 AllianceGenome:RGD:1562310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562310
Summary
Predicted to be involved in positive regulation of SREBP signaling pathway. Predicted to be located in Golgi membrane. Orthologous to human SPRING1 (SREBF pathway regulator in golgi 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 59.7), Heart (RPKM 54.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (43967146..43990083, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38306227..38329175, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (43920564..43940798, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553129 Neighboring gene uncharacterized LOC134481204 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ring finger protein, transmembrane 2 Neighboring gene uncharacterized LOC102553921 Neighboring gene harakiri, BCL2 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of SREBP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SREBP regulating gene protein
Names
UPF0454 protein C12orf49 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109066.2 → NP_001102536.1  SREBP regulating gene protein

    See identical proteins and their annotated locations for NP_001102536.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I5ZXJ0, A6J1L7, D3ZTN6
    Related
    ENSRNOP00000001485.4, ENSRNOT00000001485.5
    Conserved Domains (1) summary
    pfam10218
    Location:72 → 195
    DUF2054; Uncharacterized conserved protein (DUF2054)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    43967146..43990083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271595.1 → XP_063127665.1  SREBP regulating gene protein isoform X1

  2. XM_063271596.1 → XP_063127666.1  SREBP regulating gene protein isoform X1

  3. XM_063271597.1 → XP_063127667.1  SREBP regulating gene protein isoform X2

  4. XM_039089707.2 → XP_038945635.1  SREBP regulating gene protein isoform X3

    Conserved Domains (2) summary
    cl00342
    Location:55 → 115
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    pfam10218
    Location:72 → 91
    DUF2054; Uncharacterized conserved protein (DUF2054)
Nucleotide Protein Strain
Heading Accession and Version

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