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Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498272, updated on 3-May-2024

Summary

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Official Symbol
Uap1provided by RGD
Official Full Name
UDP-N-acetylglucosamine pyrophosphorylase 1provided by RGD
Primary source
RGD:1561967
See related
Ensembl:ENSRNOG00000002926 AllianceGenome:RGD:1561967
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561967
Summary
Enables UDP-N-acetylglucosamine diphosphorylase activity and carbohydrate binding activity. Involved in UDP-N-acetylglucosamine metabolic process. Located in cytosol. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 209.5), Lung (RPKM 149.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uap1 in Genome Data Viewer
Location:
13q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (84875719..84910706, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (82342946..82377558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (88463532..88497901, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene discoidin domain receptor tyrosine kinase 2 Neighboring gene uncharacterized LOC102549303 Neighboring gene uncharacterized LOC130014439 Neighboring gene U2AF homology motif kinase 1 Neighboring gene spermine synthase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subcellular localization and tissue distribution of sialic acid precursor-forming enzymes. Van Rinsum J, et al. Biochem J, 1983 Jan 15. PMID 6303311, Free PMC Article
  2. The cellular fate of glucose and its relevance in type 2 diabetes. Bouché C, et al. Endocr Rev, 2004 Oct. PMID 15466941
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine diphosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine diphosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine pyrophosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UDP-N-acetylhexosamine pyrophosphorylase
Names
UDP-N-acteylglucosamine pyrophosphorylase 1
NP_001178859.1
XP_006250284.1
XP_006250285.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191930.2 → NP_001178859.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AUT9, D3ZF39
    Related
    ENSRNOP00000055358.3, ENSRNOT00000058560.4
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

  2. NM_001429958.1 → NP_001416887.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001429959.1 → NP_001416888.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 3

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    84875719..84910706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250222.3 → XP_006250284.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AUT9
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

  2. XM_006250223.3 → XP_006250285.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X2

    UniProtKB/TrEMBL
    A0A8I6AUT9
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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