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OPRM1 opioid receptor mu 1 [ Homo sapiens (human) ]

Gene ID: 4988, updated on 28-Nov-2021

Summary

Official Symbol
OPRM1provided by HGNC
Official Full Name
opioid receptor mu 1provided by HGNC
Primary source
HGNC:HGNC:8156
See related
Ensembl:ENSG00000112038 MIM:600018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
Summary
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OPRM1 in Genome Data Viewer
Location:
6q25.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (154010496..154246867)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (154331631..154568001)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 896, pseudogene Neighboring gene high mobility group box 3 pseudogene 19 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene ribosomal protein L17 pseudogene 24 Neighboring gene uncharacterized LOC105378067 Neighboring gene CNKSR family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
GeneReviews: Not available
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cyclic d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), mu-opioid receptor-selective antagonist, significantly delay the febrile response induced by HIV-1 gp120, suggesting that mu-opioid receptors can regulate gp120-induced fever PubMed
env HIV-1 gp120 induces desensitization of a mu-opioid-receptor-mediated response in brain periaqueductal gray neurons PubMed
env HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR PubMed
env HIV-1 gp120 upregulates mu opiate receptor expression in human vascular endothelium; in contrast, morphine decreases mu opioid receptor expression PubMed
Tat tat The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes PubMed
tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-endorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-endorphin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables filamin binding IEA
Inferred from Electronic Annotation
more info
 
enables morphine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables morphine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled opioid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
involved_in acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to morphine IEA
Inferred from Electronic Annotation
more info
 
involved_in eating behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in estrous cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cocaine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to food IEA
Inferred from Electronic Annotation
more info
 
involved_in response to growth factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to radiation IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception NAS
Non-traceable Author Statement
more info
PubMed 
involved_in sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in spine apparatus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mu-type opioid receptor
Names
mu opiate receptor
mu opioid receptor hMOR-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021208.2 RefSeqGene

    Range
    33740..241367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1007

mRNA and Protein(s)

  1. NM_000914.5NP_000905.3  mu-type opioid receptor isoform MOR-1

    See identical proteins and their annotated locations for NP_000905.3

    Status: REVIEWED

    Source sequence(s)
    AL132774, AL136444
    Consensus CDS
    CCDS55070.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000328264.7, ENST00000330432.12
    Conserved Domains (1) summary
    cd15090
    Location:71349
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001008503.3NP_001008503.2  mu-type opioid receptor isoform MOR-1O

    See identical proteins and their annotated locations for NP_001008503.2

    Status: REVIEWED

    Source sequence(s)
    AL136444, AL445220
    Consensus CDS
    CCDS43517.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000338381.4, ENST00000337049.8
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  3. NM_001008504.4NP_001008504.2  mu-type opioid receptor isoform MOR-1A

    See identical proteins and their annotated locations for NP_001008504.2

    Status: REVIEWED

    Source sequence(s)
    AL136444
    Consensus CDS
    CCDS47508.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000411903.2, ENST00000428397.6
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  4. NM_001008505.2NP_001008505.2  mu-type opioid receptor isoform MOR-1X

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1X), also known as MOR-1R, represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1X) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL136444, AY036622, FJ041291
    Consensus CDS
    CCDS43518.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000229768.5, ENST00000229768.9
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  5. NM_001145279.4NP_001138751.1  mu-type opioid receptor isoform MOR-1i

    See identical proteins and their annotated locations for NP_001138751.1

    Status: REVIEWED

    Source sequence(s)
    AL132774, AL136444
    Consensus CDS
    CCDS47503.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    B8K2Q5
    Related
    ENSP00000394624.2, ENST00000434900.6
    Conserved Domains (2) summary
    pfam00001
    Location:180431
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:172376
    7tm_4; Olfactory receptor
  6. NM_001145280.4NP_001138752.1  mu-type opioid receptor isoform MOR-1G1

    See identical proteins and their annotated locations for NP_001138752.1

    Status: REVIEWED

    Source sequence(s)
    AL132774, AL136444
    Consensus CDS
    CCDS55071.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    B8K2Q5
    Related
    ENSP00000430876.1, ENST00000520708.5
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  7. NM_001145281.3NP_001138753.1  mu-type opioid receptor isoform MOR-1G2

    See identical proteins and their annotated locations for NP_001138753.1

    Status: REVIEWED

    Source sequence(s)
    AL132774, AL136444
    Consensus CDS
    CCDS55068.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    B8K2Q5
    Related
    ENSP00000430260.1, ENST00000518759.5
    Conserved Domains (2) summary
    pfam00001
    Location:15257
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:15202
    7tm_4; Olfactory receptor
  8. NM_001145282.2NP_001138754.1  mu-type opioid receptor isoform MOR-1B1

    See identical proteins and their annotated locations for NP_001138754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B1) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL136444, AY225404, FJ041291
    Consensus CDS
    CCDS47504.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000410497.2, ENST00000452687.6
    Conserved Domains (1) summary
    cd15090
    Location:71349
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. NM_001145283.2NP_001138755.1  mu-type opioid receptor isoform MOR-1B2

    See identical proteins and their annotated locations for NP_001138755.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B2) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL132774, AY309005, FJ041291
    Consensus CDS
    CCDS47505.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000413752.2, ENST00000435918.6
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  10. NM_001145284.3NP_001138756.1  mu-type opioid receptor isoform MOR-1B3

    See identical proteins and their annotated locations for NP_001138756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B3) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AL132774, AY309006, FJ041291
    Consensus CDS
    CCDS47506.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000399359.2, ENST00000414028.6
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  11. NM_001145285.3NP_001138757.1  mu-type opioid receptor isoform MOR-1B4

    Status: REVIEWED

    Source sequence(s)
    AL132774, AL136444
    Consensus CDS
    CCDS55069.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000430097.1, ENST00000524163.5
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  12. NM_001145286.3NP_001138758.1  mu-type opioid receptor isoform MOR-1B5

    Status: REVIEWED

    Source sequence(s)
    AL132774, AL136444
    Consensus CDS
    CCDS47507.1
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5
    Related
    ENSP00000403549.2, ENST00000419506.6
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  13. NM_001145287.3NP_001138759.1  mu-type opioid receptor isoform MOR-1G1

    See identical proteins and their annotated locations for NP_001138759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1K1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
    Source sequence(s)
    AL132774, AL136444, EU362990
    Consensus CDS
    CCDS55071.1
    UniProtKB/Swiss-Prot
    P35372
    Related
    ENSP00000429373.1, ENST00000522236.1
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  14. NM_001285522.1NP_001272451.1  mu-type opioid receptor isoform MOR-1S

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1S) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks two alternate internal exons, compared to variant MOR-1i. The resulting isoform (MOR-1S) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
    Source sequence(s)
    AL132774, FJ041290, FJ041291
    UniProtKB/TrEMBL
    G8XRH4, G8XRH5
    Conserved Domains (2) summary
    cd14964
    Location:7396
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:7196
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. NM_001285523.3NP_001272452.1  mu-type opioid receptor isoform MOR-1A2

    See identical proteins and their annotated locations for NP_001272452.1

    Status: REVIEWED

    Source sequence(s)
    AL136444
    UniProtKB/Swiss-Prot
    P35372
    UniProtKB/TrEMBL
    G8XRH5, L0E130
    Related
    ENSP00000353598.5, ENST00000360422.8
    Conserved Domains (2) summary
    pfam00001
    Location:87338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:79283
    7tm_4; Olfactory receptor
  16. NM_001285524.1NP_001272453.1  mu-type opioid receptor isoform MOR-1i

    See identical proteins and their annotated locations for NP_001272453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1CA) represents use of an alternate promoter and 5' UTR, compared to variant MOR-1i. Variants MOR-1i and MOR-1CA encode the same isoform (MOR-1i).
    Source sequence(s)
    AL132774, FJ041292
    Consensus CDS
    CCDS47503.1
    UniProtKB/Swiss-Prot
    P35372
    Conserved Domains (2) summary
    pfam00001
    Location:180431
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:172376
    7tm_4; Olfactory receptor
  17. NM_001285526.2NP_001272455.1  mu-type opioid receptor isoform MOR-1G1

    See identical proteins and their annotated locations for NP_001272455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1K2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
    Source sequence(s)
    AL132774, AL136444, EU360599
    Consensus CDS
    CCDS55071.1
    UniProtKB/Swiss-Prot
    P35372
    Related
    ENSP00000429719.1, ENST00000522555.5
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  18. NM_001285527.1NP_001272456.1  mu-type opioid receptor isoform MOR-1W

    See identical proteins and their annotated locations for NP_001272456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1W; also known as mu3-like and MOR-1A delta) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1W) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AY364890
    UniProtKB/Swiss-Prot
    P35372
    Related
    ENST00000522382.1
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  19. NM_001285528.2NP_001272457.1  mu-type opioid receptor isoform MOR-3

    See identical proteins and their annotated locations for NP_001272457.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-3; also known as mu3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-3) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
    Source sequence(s)
    AY195733, AY364890
    UniProtKB/Swiss-Prot
    P35372
    Related
    ENST00000521106.1
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor

RNA

  1. NR_104348.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Y3; also known as MOR-1V) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL132774, FJ041291, FJ041293, FJ041294
  2. NR_104349.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Y2) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY225404, FJ041291, FJ041294
  3. NR_104350.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Z) represents use of an alternate promoter and lacks an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL132774, FJ041291, HQ699462
  4. NR_104351.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1Y) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL132774, AY309009, FJ041291
    Related
    ENST00000519083.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    154010496..154246867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010907.2XP_016866396.1  mu-type opioid receptor isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:135159
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:133180
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_011535862.2XP_011534164.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534164.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  3. XM_011535856.2XP_011534158.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534158.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  4. XM_011535853.2XP_011534155.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534155.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  5. XM_017010906.2XP_016866395.1  mu-type opioid receptor isoform X2

    UniProtKB/Swiss-Prot
    P35372
    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  6. XM_017010903.2XP_016866392.1  mu-type opioid receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  7. XM_011535851.3XP_011534153.1  mu-type opioid receptor isoform X1

    See identical proteins and their annotated locations for XP_011534153.1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  8. XM_017010905.1XP_016866394.1  mu-type opioid receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
  9. XM_017010904.1XP_016866393.1  mu-type opioid receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56183
    7tm_4; Olfactory receptor
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