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Fis1 Fission, mitochondrial 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49892, updated on 26-Apr-2024

Summary

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Official Symbol
Fis1provided by FlyBase
Official Full Name
Fission, mitochondrial 1provided by FlyBase
Primary source
FLYBASE:FBgn0039969
Locus tag
Dmel_CG17510
See related
AllianceGenome:FB:FBgn0039969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE29957; bs15a08.y1; CG17510; dFis1; Dmel\CG17510; fis1; FIS1; NEST:bs15a08
Summary
Involved in mitochondrion organization and positive regulation of mitochondrial fission. Predicted to be located in peroxisomal membrane. Predicted to be integral component of mitochondrial outer membrane and integral component of peroxisomal membrane. Is expressed in adult head and organism. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
41F5-41F5; 2-55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5603587..5604834, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1491092..1492339, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 50 member B3 Neighboring gene Troponin C isoform 4 Neighboring gene uncharacterized protein Neighboring gene hermes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila. Lee TT, et al. Aging Cell, 2021 Jun. PMID 34061429, Free PMC Article
  2. D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries. Debattisti V, et al. Mol Cell Neurosci, 2013 Jul. PMID 22940086
  3. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Yang Y, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18443288, Free PMC Article
  4. Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation. Chen Z, et al. J Cell Biol, 2020 Jul 6. PMID 32375181, Free PMC Article
  5. Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing. Liu B, et al. Sci Rep, 2016 Oct 11. PMID 27725692, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila.
    Title: Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fragmentation involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Fission, mitochondrial 1
Names
CG17510-PA
CG17510-PC
CG17510-PD
CG17510-PE
CG17510-PF
CG17510-PG
Fis1-PA
Fis1-PC
Fis1-PD
Fis1-PE
Fis1-PF
Fis1-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5603587..5604834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143843.4 → NP_652100.1  Fission, mitochondrial 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652100.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZT2
    Related
    FBpp0085409
    Conserved Domains (1) summary
    cl21750
    Location:1 → 64
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

  2. NM_001144135.2 → NP_001137607.1  Fission, mitochondrial 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137607.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6G3, B7YZT2, B7YZT3, Q8SYX2
    Conserved Domains (1) summary
    cd12212
    Location:9 → 120
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

  3. NM_001299211.1 → NP_001286140.1  Fission, mitochondrial 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286140.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZT2
    Conserved Domains (1) summary
    cl21750
    Location:1 → 64
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

  4. NM_165439.4 → NP_724420.1  Fission, mitochondrial 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724420.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZT2
    Related
    FBpp0271717
    Conserved Domains (2) summary
    cd12212
    Location:13 → 44
    Fis1; TPR repeat [structural motif]
    cl21750
    Location:1 → 64
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

  5. NM_001144136.3 → NP_001137608.1  Fission, mitochondrial 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZT2
    Conserved Domains (1) summary
    cd12212
    Location:9 → 120
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

  6. NM_001144137.3 → NP_001137609.1  Fission, mitochondrial 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137609.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZT2
    Conserved Domains (2) summary
    cd12212
    Location:13 → 44
    Fis1; TPR repeat [structural motif]
    cl21750
    Location:1 → 64
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7YZT2.1 B7YZT2

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