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Syne1 spectrin repeat containing nuclear envelope protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499010, updated on 13-Apr-2024

Summary

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Symbol
Syne1provided by RGD
Full Name
spectrin repeat containing nuclear envelope protein 1provided by RGD
Primary source
RGD:620546
See related
Ensembl:ENSRNOG00000018960 AllianceGenome:RGD:620546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CPG2; Myne-1
Summary
Enables enzyme binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of mesenchymal cell apoptotic process; negative regulation of mini excitatory postsynaptic potential; and regulation of receptor-mediated endocytosis. Located in several cellular components, including dendritic spine head; midbody; and nuclear membrane. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 659.2), Lung (RPKM 334.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q11
Exon count:
150
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43917640..44388802, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (41512146..41983382, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41844840..42086662, complement) , (41608287..41763591, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor 1 Neighboring gene uncharacterized LOC134482628 Neighboring gene small nucleolar RNA SNORD88 Neighboring gene uncharacterized LOC134482627 Neighboring gene uncharacterized LOC134482626 Neighboring gene RNA, U6 small nuclear 959 Neighboring gene myc target 1 Neighboring gene vasoactive intestinal peptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro. Yang W, et al. Mol Med Rep, 2015 Jan. PMID 25339194, Free PMC Article
  2. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Loebrich S, et al. Proc Natl Acad Sci U S A, 2013 Nov 19. PMID 24191017, Free PMC Article
  3. Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells. Yang W, et al. Int J Mol Med, 2013 Oct. PMID 23863972
  4. CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Cottrell JR, et al. Neuron, 2004 Nov 18. PMID 15541315, Free PMC Article
  5. The spectrin family member Syne-1 functions in retrograde transport from Golgi to ER. Gough LL, et al. Biochim Biophys Acta, 2004 Jul 23. PMID 15276322

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
    Title: Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
  2. Through direct interactions with F-actin and EndoB2, CPG2 physically bridges the spine cytoskeleton and the endocytic machinery, and this tripartite association is critical specifically for activity-dependent clathrin-mediated endocytosis of synaptic glutamate receptors.
    Title: CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors.
  3. the expression of nesprin-1 protein was higher during the differentiation process of MSCs and may have an important role in mediating MSC differentiation.
    Title: Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro.
  4. In the process of mesenchymal stem cell proliferation and differentiation, the upregulation of the protein expression of nesprin-1 may maintain the stability of the cell nuclear membrane and reduce the apoptosis of the mesenchymal stem cells.
    Title: Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells.
  5. CPG2 regulates synaptic AMPAR endocytosis through its association with the spine cytoskeleton and functions as a nexus for integrating PKA signaling with this process.
    Title: Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.
  6. Through the direct binding of the nesprin-1alpha amino-terminal dimerization domain to the third mAKAP spectrin repeat, nesprin-1alpha targets mAKAP to the nuclear envelope.
    Title: Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope.
  7. CPG2 is a key component of a specialized postsynaptic endocytic mechanism devoted to the internalization of synaptic proteins, including glutamate receptors.
    Title: CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors.
  8. role for in facilitating retrograde vesicular trafficking from the Golgi to the ER
    Title: The spectrin family member Syne-1 functions in retrograde transport from Golgi to ER.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeleton-nuclear membrane anchor activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac muscle cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in centrosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mesenchymal cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mini excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear matrix anchoring at nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nuclear migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine head IDA
Inferred from Direct Assay
more info
 PubMed 
part_of meiotic nuclear membrane microtubule tethering complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nesprin-1
Names
nesprin-1-like
spectrin repeat containing, nuclear envelope 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419849.1 → NP_001406778.1  nesprin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    43917640..44388802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270573.1 → XP_063126643.1  nesprin-1 isoform X9

  2. XM_063270583.1 → XP_063126653.1  nesprin-1 isoform X12

  3. XM_063270581.1 → XP_063126651.1  nesprin-1 isoform X12

  4. XM_063270574.1 → XP_063126644.1  nesprin-1 isoform X10

  5. XM_039101500.2 → XP_038957428.1  nesprin-1 isoform X9

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1151 → 1585
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1404 → 2254
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7993 → 8203
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4951 → 5786
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4411 → 5236
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8753 → 8809
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2398 → 2603
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_039101511.2 → XP_038957439.1  nesprin-1 isoform X29

    UniProtKB/TrEMBL
    A0A5P8DHK4
    Conserved Domains (9) summary
    PTZ00121
    Location:1161 → 1595
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1414 → 2264
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7951 → 8161
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4961 → 5796
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4421 → 5246
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8663 → 8719
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175 → 283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2408 → 2613
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_039101503.2 → XP_038957431.1  nesprin-1 isoform X15

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1161 → 1595
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1414 → 2264
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7998 → 8208
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4961 → 5796
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4421 → 5246
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8735 → 8791
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175 → 283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2408 → 2613
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_039101499.2 → XP_038957427.1  nesprin-1 isoform X7

    UniProtKB/TrEMBL
    A0A5P8DHN0, A0A8I5ZJB9
    Related
    ENSRNOP00000076933.1
    Conserved Domains (9) summary
    PTZ00121
    Location:1161 → 1595
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1414 → 2264
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7998 → 8208
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4961 → 5796
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4421 → 5246
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8758 → 8814
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175 → 283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2408 → 2613
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  9. XM_039101497.2 → XP_038957425.1  nesprin-1 isoform X5

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1161 → 1595
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1414 → 2264
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4961 → 5796
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4421 → 5246
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8763 → 8819
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175 → 283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2408 → 2613
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  10. XM_063270618.1 → XP_063126688.1  nesprin-1 isoform X24

  11. XM_017590500.3 → XP_017445989.2  nesprin-1 isoform X23

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (8) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8010 → 8220
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  12. XM_039101509.2 → XP_038957437.1  nesprin-1 isoform X21

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (8) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8010 → 8220
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  13. XM_039101506.2 → XP_038957434.1  nesprin-1 isoform X19

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7958 → 8168
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4916 → 5751
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4376 → 5201
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8718 → 8774
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  14. XM_039101510.2 → XP_038957438.1  nesprin-1 isoform X22

    UniProtKB/TrEMBL
    A0A5P8DHK4
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7958 → 8168
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8670 → 8726
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  15. XM_063270600.1 → XP_063126670.1  nesprin-1 isoform X18

  16. XM_039101504.2 → XP_038957432.1  nesprin-1 isoform X16

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7963 → 8173
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8723 → 8779
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  17. XM_039101496.2 → XP_038957424.1  nesprin-1 isoform X4

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8005 → 8215
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8765 → 8821
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  18. XM_039101495.2 → XP_038957423.1  nesprin-1 isoform X3

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8006 → 8216
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8766 → 8822
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  19. XM_039101494.2 → XP_038957422.1  nesprin-1 isoform X2

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8009 → 8219
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8769 → 8825
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  20. XM_063270606.1 → XP_063126676.1  nesprin-1 isoform X20

  21. XM_039101505.2 → XP_038957433.1  nesprin-1 isoform X17

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8010 → 8220
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8722 → 8778
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  22. XM_039101502.2 → XP_038957430.1  nesprin-1 isoform X11

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8010 → 8220
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8747 → 8803
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  23. XM_039101493.2 → XP_038957421.1  nesprin-1 isoform X1

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8010 → 8220
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8770 → 8826
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  24. XM_063270562.1 → XP_063126632.1  nesprin-1 isoform X5

  25. XM_039101492.2 → XP_038957420.1  nesprin-1 isoform X1

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1168 → 1602
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1421 → 2271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8010 → 8220
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4968 → 5803
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4428 → 5253
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8770 → 8826
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2415 → 2620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  26. XM_063270589.1 → XP_063126659.1  nesprin-1 isoform X14

  27. XM_063270568.1 → XP_063126638.1  nesprin-1 isoform X8

  28. XM_063270587.1 → XP_063126657.1  nesprin-1 isoform X13

  29. XM_039101498.2 → XP_038957426.1  nesprin-1 isoform X6

    UniProtKB/TrEMBL
    A0A5P8DHN0
    Conserved Domains (9) summary
    PTZ00121
    Location:1159 → 1593
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:1412 → 2262
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8001 → 8211
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4959 → 5794
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:4419 → 5244
    CCDC158; Coiled-coil domain-containing protein 158
    pfam10541
    Location:8761 → 8817
    KASH; Nuclear envelope localization domain
    cd21241
    Location:15 → 134
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:173 → 281
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:2406 → 2611
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  30. XM_063270623.1 → XP_063126693.1  nesprin-1 isoform X25

  31. XM_006227851.5 → XP_006227913.1  nesprin-1 isoform X26

    UniProtKB/TrEMBL
    Q8VHJ9
    Conserved Domains (4) summary
    COG1196
    Location:219 → 965
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:2222 → 2432
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:2959 → 3015
    KASH; Nuclear envelope localization domain
    cl02488
    Location:186 → 409
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  32. XM_006227852.5 → XP_006227914.1  nesprin-1 isoform X28

    UniProtKB/TrEMBL
    A0A8I6B1X1, A6KIM8
    Related
    ENSRNOP00000095051.1
    Conserved Domains (2) summary
    cd00176
    Location:155 → 365
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:892 → 948
    KASH; Nuclear envelope localization domain

  33. XM_063270634.1 → XP_063126704.1  nesprin-1 isoform X27

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001029909.1: Suppressed sequence

    Description
    NM_001029909.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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