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Serac1 serine active site containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499015, updated on 13-Apr-2024

Summary

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Official Symbol
Serac1provided by RGD
Official Full Name
serine active site containing 1provided by RGD
Primary source
RGD:1565064
See related
Ensembl:ENSRNOG00000017889 AllianceGenome:RGD:1565064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565064
Summary
Predicted to be involved in intracellular cholesterol transport and phosphatidylglycerol acyl-chain remodeling. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondria-associated endoplasmic reticulum membrane; and mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 38.7), Testes (RPKM 31.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49025845..49061853, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46620741..46656801, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (46934499..46978264, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 Neighboring gene uncharacterized LOC134482645 Neighboring gene uncharacterized LOC134482650 Neighboring gene uncharacterized LOC120099116 Neighboring gene uncharacterized LOC102551377 Neighboring gene general transcription factor IIH subunit 5 Neighboring gene TUB like protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Wortmann SB, et al. Nat Genet, 2012 Jun 10. PMID 22683713
  2. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylglycerol acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein SERAC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400935.1 → NP_001387864.1  protein SERAC1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6B543
    Related
    ENSRNOP00000096974.1, ENSRNOT00000095436.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    49025845..49061853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099712.2 → XP_038955640.1  protein SERAC1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A2J2, A6KP00, D4ACP8
    Related
    ENSRNOP00000087053.1
    Conserved Domains (1) summary
    cl21494
    Location:365 → 535
    Abhydrolase; alpha/beta hydrolases

  2. XM_063270670.1 → XP_063126740.1  protein SERAC1 isoform X2

  3. XM_063270668.1 → XP_063126738.1  protein SERAC1 isoform X1

  4. XM_039099721.2 → XP_038955649.1  protein SERAC1 isoform X4

    Conserved Domains (1) summary
    cl21494
    Location:122 → 292
    Abhydrolase; alpha/beta hydrolases

RNA

  1. XR_010055964.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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