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Scd4 stearoyl-coenzyme A desaturase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499358, updated on 29-Feb-2024

Summary

Official Symbol
Scd4provided by RGD
Official Full Name
stearoyl-coenzyme A desaturase 4provided by RGD
Primary source
RGD:1563648
See related
Ensembl:ENSRNOG00000032554 AllianceGenome:RGD:1563648
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563648
Summary
Predicted to enable iron ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Predicted to be involved in several processes, including cellular response to nutrient; monounsaturated fatty acid biosynthetic process; and unsaturated fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 388.9), Liver (RPKM 272.7) and 9 other tissues See more
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Genomic context

Location:
1q54
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (253152519..253165216)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (243203433..243216007)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (264094007..264105473)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349475 Neighboring gene stearoyl-Coenzyme A desaturase 2 Neighboring gene 5S ribosomal RNA Neighboring gene stearoyl-CoA desaturase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoyl-CoA 9-desaturase activity ISO
Inferred from Sequence Orthology
more info
 
enables stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables stearoyl-CoA 9-desaturase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to nutrient ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in monounsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
stearoyl-CoA desaturase 4
Names
acyl-CoA desaturase 4
XP_574671.7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    253152519..253165216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_574671.9XP_574671.7  stearoyl-CoA desaturase 4

    UniProtKB/TrEMBL
    A6JHF8, D4ABJ9
    Related
    ENSRNOP00000017834.6
    Conserved Domains (1) summary
    cd03505
    Location:122359
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...