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Tyw3 tRNA-yW synthesizing protein 3 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 499731, updated on 3-Apr-2024

Summary

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Official Symbol
Tyw3provided by RGD
Official Full Name
tRNA-yW synthesizing protein 3 homologprovided by RGD
Primary source
RGD:1559623
See related
Ensembl:ENSRNOG00000028328 AllianceGenome:RGD:1559623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559623
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be active in cytoplasm. Orthologous to human TYW3 (tRNA-yW synthesizing protein 3 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 61.7), Heart (RPKM 39.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tyw3 in Genome Data Viewer
Location:
2q45
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (246189627..246211737, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (243529912..243552043, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260861825..260884270, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 20 Neighboring gene voltage-dependent anion channel 1, pseudogene 14 Neighboring gene 40S ribosomal protein S7 pseudogene Neighboring gene crystallin zeta Neighboring gene uncharacterized LOC120100979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA wybutosine-synthesizing protein 3 homolog
NP_001386344.1
NP_001386345.1
XP_038959818.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399415.1 → NP_001386344.1  tRNA wybutosine-synthesizing protein 3 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HWQ1
    Related
    ENSRNOP00000037831.5, ENSRNOT00000032874.7
    Conserved Domains (1) summary
    pfam02676
    Location:10 → 193
    TYW3; Methyltransferase TYW3

  2. NM_001399416.1 → NP_001386345.1  tRNA wybutosine-synthesizing protein 3 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZSZ8
    Related
    ENSRNOP00000082080.1, ENSRNOT00000105899.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    246189627..246211737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103890.2 → XP_038959818.1  tRNA wybutosine-synthesizing protein 3 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZL47, D3ZHR8
    Related
    ENSRNOP00000078566.1
    Conserved Domains (1) summary
    pfam02676
    Location:45 → 204
    TYW3; Methyltransferase TYW3
Nucleotide Protein Strain
Heading Accession and Version

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