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Zfyve19 zinc finger FYVE-type containing 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499871, updated on 5-Mar-2024

Summary

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Official Symbol
Zfyve19provided by RGD
Official Full Name
zinc finger FYVE-type containing 19provided by RGD
Primary source
RGD:1561576
See related
Ensembl:ENSRNOG00000012528 AllianceGenome:RGD:1561576
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Predicted to be active in centrosome; cleavage furrow; and midbody. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 107.6), Lung (RPKM 77.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q35
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126649625..126657812)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106195779..106203969)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111013856..111021841)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase I feedback regulator Neighboring gene similar to human chromosome 15 open reading frame 62 Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14D Neighboring gene uncharacterized LOC134486140 Neighboring gene serine peptidase inhibitor, Kunitz type 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. Thoresen SB, et al. Nat Cell Biol, 2014 Jun. PMID 24814515
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124714

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in abscission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in abscission ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
abscission/NoCut checkpoint regulator
Names
zinc finger FYVE domain-containing protein 19
zinc finger, FYVE domain containing 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034948.1 → NP_001030120.1  abscission/NoCut checkpoint regulator

    See identical proteins and their annotated locations for NP_001030120.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099795
    UniProtKB/TrEMBL
    A0A8J8Y9Q4, F1LQM4, Q499R6
    Related
    ENSRNOP00000016854.5, ENSRNOT00000016854.6
    Conserved Domains (1) summary
    cd15749
    Location:4 → 54
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    126649625..126657812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105681.2 → XP_038961609.1  abscission/NoCut checkpoint regulator isoform X1

    UniProtKB/TrEMBL
    A0A8J8Y9Q4
    Conserved Domains (2) summary
    cd15749
    Location:4 → 54
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:340 → 384
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

  2. XM_039105683.2 → XP_038961611.1  abscission/NoCut checkpoint regulator isoform X3

    UniProtKB/TrEMBL
    A0A8J8Y9Q4
    Conserved Domains (2) summary
    cd15749
    Location:4 → 54
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:334 → 378
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

  3. XM_039105682.2 → XP_038961610.1  abscission/NoCut checkpoint regulator isoform X2

    UniProtKB/TrEMBL
    A0A8J8Y9Q4
    Conserved Domains (2) summary
    cd15749
    Location:4 → 54
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:339 → 383
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

  4. XM_039105685.2 → XP_038961613.1  abscission/NoCut checkpoint regulator isoform X4

    Conserved Domains (1) summary
    cd19817
    Location:196 → 240
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

  5. XM_063284365.1 → XP_063140435.1  abscission/NoCut checkpoint regulator isoform X5

  6. XM_039105686.2 → XP_038961614.1  abscission/NoCut checkpoint regulator isoform X4

    Conserved Domains (1) summary
    cd19817
    Location:196 → 240
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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