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Asb10 ankyrin repeat and SOCS box-containing 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499972, updated on 5-Mar-2024

Summary

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Official Symbol
Asb10provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 10provided by RGD
Primary source
RGD:1562922
See related
Ensembl:ENSRNOG00000024885 AllianceGenome:RGD:1562922
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562922
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Orthologous to human ASB10 (ankyrin repeat and SOCS box containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 160.1) and Heart (RPKM 94.2) See more
Orthologs
human mouse all
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Genomic context

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Location:
4q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11522531..11531946)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10630318..10644270)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7158293..7167505)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily F member 2 Neighboring gene IQ motif containing with AAA domain 1 like Neighboring gene gastrulation brain homeobox 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134486542

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Variants in ASB10 are associated with open-angle glaucoma. Pasutto F, et al. Hum Mol Genet, 2012 Mar 15. PMID 22156576, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 10
Names
ankyrin repeat and SOCS box-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109216.2 → NP_001102686.1  ankyrin repeat and SOCS box protein 10

    See identical proteins and their annotated locations for NP_001102686.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168867
    UniProtKB/TrEMBL
    A0A8J8YAH4, B5DEZ7, F1LQJ8
    Related
    ENSRNOP00000037231.5, ENSRNOT00000037446.5
    Conserved Domains (6) summary
    smart00248
    Location:116 → 141
    ANK; ankyrin repeats
    cd00204
    Location:146 → 312
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03587
    Location:419 → 458
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    pfam12796
    Location:150 → 243
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:115 → 166
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    11522531..11531946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235959.5 → XP_006236021.1  ankyrin repeat and SOCS box protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A096MJQ3
    Related
    ENSRNOP00000068220.1
    Conserved Domains (6) summary
    smart00248
    Location:103 → 128
    ANK; ankyrin repeats
    COG0666
    Location:64 → 286
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:133 → 299
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03587
    Location:406 → 445
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    pfam12796
    Location:253 → 343
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:133 → 163
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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