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Plekha8 pleckstrin homology domain containing A8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500132, updated on 13-Apr-2024

Summary

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Official Symbol
Plekha8provided by RGD
Official Full Name
pleckstrin homology domain containing A8provided by RGD
Primary source
RGD:1563940
See related
Ensembl:ENSRNOG00000009971 AllianceGenome:RGD:1563940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FAPP-2; RGD1563940
Summary
Predicted to enable several functions, including identical protein binding activity; lipid transfer activity; and phospholipid binding activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane lipid transfer. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in cytosol. Orthologous to human PLEKHA8 (pleckstrin homology domain containing A8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 55.4), Testes (RPKM 46.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85053765..85104376)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83723470..83774081)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84770294..84820887)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene FKBP prolyl isomerase 14 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 3 Neighboring gene uncharacterized LOC134486771 Neighboring gene maturin, neural progenitor differentiation regulator homolog Neighboring gene uncharacterized LOC100909941

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. D'Angelo G, et al. Nature, 2007 Sep 6. PMID 17687330
  2. Golgi protein FAPP2 tubulates membranes. Cao X, et al. Proc Natl Acad Sci U S A, 2009 Dec 15. PMID 19940249, Free PMC Article
  3. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Godi A, et al. Nat Cell Biol, 2004 May. PMID 15107860
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide 1-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide 1-phosphate transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
  
enables ceramide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycolipid binding ISO
Inferred from Sequence Orthology
more info
  
enables glycolipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycolipid transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables glycolipid transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ER to Golgi ceramide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in ER to Golgi ceramide transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ceramide 1-phosphate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intermembrane lipid transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 8
Names
PH domain-containing family A member 8
phosphatidylinositol-four-phosphate adapter protein 2
phosphoinositol 4-phosphate adapter protein 2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109235.2 → NP_001102705.1  pleckstrin homology domain-containing family A member 8

    See identical proteins and their annotated locations for NP_001102705.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    D3ZY60
    Related
    ENSRNOP00000013528.5, ENSRNOT00000013528.7
    Conserved Domains (3) summary
    cd01247
    Location:1 → 100
    PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:1 → 93
    PH; PH domain
    pfam08718
    Location:334 → 471
    GLTP; Glycolipid transfer protein (GLTP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    85053765..85104376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108138.2 → XP_038964066.1  pleckstrin homology domain-containing family A member 8 isoform X1

    Conserved Domains (1) summary
    cd01247
    Location:1 → 100
    PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZY60.1 GenPept UniProtKB/Swiss-Prot:D3ZY60

Gene LinkOut

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