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Itpk1 inositol-tetrakisphosphate 1-kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 500709, updated on 13-Apr-2024

Summary

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Official Symbol
Itpk1provided by RGD
Official Full Name
inositol-tetrakisphosphate 1-kinaseprovided by RGD
Primary source
RGD:1595691
See related
Ensembl:ENSRNOG00000008051 AllianceGenome:RGD:1595691
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphotransferase activity, alcohol group as acceptor. Predicted to be involved in inositol phosphorylation and necroptotic process. Predicted to act upstream of or within neural tube development. Predicted to be located in apical plasma membrane. Orthologous to human ITPK1 (inositol-tetrakisphosphate 1-kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 48.7), Thymus (RPKM 39.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127475589..127609320, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121710750..121844501, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126448920..126582188, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692694 Neighboring gene chromogranin A Neighboring gene uncharacterized LOC102548189 Neighboring gene uncharacterized LOC102548370 Neighboring gene modulator of apoptosis 1 Neighboring gene GON7 subunit of KEOPS complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Wilson MP, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19482943, Free PMC Article
  2. Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase. Yang X, et al. Biochem J, 2000 Nov 1. PMID 11042108, Free PMC Article
  3. Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. Wilson MP, et al. J Biol Chem, 1996 May 17. PMID 8662638
  4. Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. Yang L, et al. J Cell Sci, 2006 Apr 1. PMID 16537650
  5. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Dovey CM, et al. Mol Cell, 2018 Jun 7. PMID 29883610, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol tetrakisphosphate 1-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol tetrakisphosphate 1-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol tetrakisphosphate 6-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,3,4-trisphosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,3,4-trisphosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,3,4-trisphosphate 6-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,3,4-trisphosphate 6-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol trisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inositol-tetrakisphosphate 1-kinase
Names
inositol 1,3,4-triphosphate 5/6 kinase
NP_001178914.1
XP_008763064.1
XP_017449793.1
XP_038968683.1
XP_063118403.1
XP_063118404.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191985.1 → NP_001178914.1  inositol-tetrakisphosphate 1-kinase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AUY6, D3ZQM7
    Related
    ENSRNOP00000010656.7, ENSRNOT00000010656.8
    Conserved Domains (1) summary
    cl17255
    Location:1 → 318
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    127475589..127609320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112755.2 → XP_038968683.1  inositol-tetrakisphosphate 1-kinase isoform X4

    Conserved Domains (1) summary
    cl17255
    Location:1 → 241
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. XM_017594304.3 → XP_017449793.1  inositol-tetrakisphosphate 1-kinase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K7L4, A0A8I6AUY6
    Related
    ENSRNOP00000074255.1

  3. XM_063262334.1 → XP_063118404.1  inositol-tetrakisphosphate 1-kinase isoform X4

  4. XM_008764842.4 → XP_008763064.1  inositol-tetrakisphosphate 1-kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I6AUY6
    Related
    ENSRNOP00000097242.1
    Conserved Domains (1) summary
    cl17255
    Location:7 → 327
    ATP-grasp_4; ATP-grasp domain

  5. XM_063262333.1 → XP_063118403.1  inositol-tetrakisphosphate 1-kinase isoform X3

    UniProtKB/TrEMBL
    A0A8I6AUQ3
Nucleotide Protein Strain
Heading Accession and Version

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