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Ccdc134 coiled-coil domain containing 134 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500909, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc134provided by RGD
Official Full Name
coiled-coil domain containing 134provided by RGD
Primary source
RGD:1559657
See related
Ensembl:ENSRNOG00000007262 AllianceGenome:RGD:1559657
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within angiogenesis and animal organ development. Predicted to be located in endoplasmic reticulum; extracellular region; and nucleus. Orthologous to human CCDC134 (coiled-coil domain containing 134). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 75.9), Thymus (RPKM 56.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccdc134 in Genome Data Viewer
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115526537..115539155)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113644557..113659050)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123362471..123376930)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC100362109 Neighboring gene meiotic double-stranded break formation protein 1 Neighboring gene uncharacterized LOC134479947 Neighboring gene sterol regulatory element binding transcription factor 2 Neighboring gene microRNA 33 Neighboring gene shisa family member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CCDC134 serves a crucial role in embryonic development. Yu B, et al. Int J Mol Med, 2018 Jan. PMID 29115376, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic liver development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024355.1 → NP_001019526.1  coiled-coil domain-containing protein 134 precursor

    See identical proteins and their annotated locations for NP_001019526.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088206
    UniProtKB/Swiss-Prot
    Q5M862
    UniProtKB/TrEMBL
    A6HT46
    Conserved Domains (1) summary
    pfam15002
    Location:23 → 195
    ERK-JNK_inhib; ERK and JNK pathways, inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115526537..115539155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079765.2 → XP_038935693.1  coiled-coil domain-containing protein 134 isoform X1

    Conserved Domains (1) summary
    pfam15002
    Location:4 → 95
    ERK-JNK_inhib; ERK and JNK pathways, inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M862.1 GenPept UniProtKB/Swiss-Prot:Q5M862

Gene LinkOut

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