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Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501653, updated on 2-Apr-2024

Summary

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Official Symbol
Suv39h1-ps1provided by RGD
Official Full Name
SUV39H1 histone lysine methyltransferase, pseudogene 1provided by RGD
Primary source
RGD:1565692
See related
AllianceGenome:RGD:1565692
Gene type
pseudo
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Suv39h1; RGD1565692
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone methyltransferase activity (H3-K9 specific); and protein N-terminus binding activity. Involved in response to amphetamine and response to nutrient levels. Predicted to be located in nucleus and rDNA heterochromatin. Predicted to be part of chromatin silencing complex. Biomarker of pre-malignant neoplasm. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
Xq36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (146828818..146831485, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (141792589..141795257, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (146532002..146533538, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene protein kinase, cAMP dependent regulatory, type I, alpha, pseudogene 1 Neighboring gene 60S ribosomal protein L21-like Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 11 Neighboring gene eukaryotic translation initiation factor 3 subunit E, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suv39h1 downregulation inhibits neointimal hyperplasia after vascular injury. Zhang J, et al. Atherosclerosis, 2019 Sep. PMID 31330382
  2. Long non-coding RNA MALAT1 promotes cardiac remodeling in hypertensive rats by inhibiting the transcription of MyoD. Li D, et al. Aging (Albany NY), 2019 Oct 15. PMID 31619581, Free PMC Article
  3. Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats. Yang B, et al. Cell Physiol Biochem, 2014. PMID 24752040
  4. Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke. Sharifulina S, et al. Int J Mol Sci, 2021 Nov 19. PMID 34830365, Free PMC Article
  5. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. Davison JM, et al. J Biol Chem, 2009 Jan 23. PMID 19001366, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke.
    Title: Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke.
  2. Long non-coding RNA MALAT1 promotes cardiac remodeling in hypertensive rats by inhibiting the transcription of MyoD.
    Title: Long non-coding RNA MALAT1 promotes cardiac remodeling in hypertensive rats by inhibiting the transcription of MyoD.
  3. Suv39h1 downregulation effectively inhibited neointimal hyperplasia after vascular injury.
    Title: Suv39h1 downregulation inhibits neointimal hyperplasia after vascular injury.
Submit: New GeneRIF Correction

General gene information

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Markers

Other Names

  • SUV39H1 histone lysine methyltransferase
  • histone-lysine N-methyltransferase SUV39H1-like
  • suppressor of variegation 3-9 homolog 1

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 trimethyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9me2 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic programming in the zygotic pronuclei ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in rDNA heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by glucose ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin silencing complex ISO
Inferred from Sequence Orthology
more info
  
part_of eNoSc complex ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of rDNA heterochromatin ISO
Inferred from Sequence Orthology
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_079388.2 

    Range
    101..2768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    146828818..146831485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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