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Slfn3 schlafen family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501712, updated on 10-May-2024

Summary

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Symbol
Slfn3provided by RGD
Full Name
schlafen family member 3provided by RGD
Primary source
RGD:1564411
See related
AllianceGenome:RGD:1564411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slfn4; RGD1564411
Summary
Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 199.5), Spleen (RPKM 168.0) and 7 other tissues See more
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Genomic context

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See Slfn3 in Genome Data Viewer
Location:
10q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68515815..68557674)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68020482..68060248)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70438012..70477259)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene schlafen family member 1 Neighboring gene schlafen family member 4 Neighboring gene glutathione S-transferase, alpha 4 like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene schlafen family member 4 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Schlafen 3 Mediates the Differentiating Effects of Cdx2 in Rat IEC-Cdx2L1 Enterocytes. Walsh MF, et al. J Invest Surg, 2015. PMID 26268420, Free PMC Article
  2. Gene expression profiling in lung fibroblasts reveals new players in alveolarization. Boucherat O, et al. Physiol Genomics, 2007 Dec 19. PMID 17911382
  3. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Schwarz DA, et al. Immunity, 1998 Nov. PMID 9846487

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
schlafen 4; schlafen family member 2
Names
schlafen 3
schlafen family member 12-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430257.1 → NP_001417186.1  schlafen 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    68515815..68557674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597673.3 → XP_017453162.1  schlafen family member 2

    UniProtKB/TrEMBL
    A0A8I5Y7C4
    Conserved Domains (1) summary
    PHA02782
    Location:100 → 389
    PHA02782; hypothetical protein; Provisional

  2. XM_017597675.3 → XP_017453164.1  schlafen family member 2

    UniProtKB/TrEMBL
    A0A8I5Y7C4
    Conserved Domains (1) summary
    PHA02782
    Location:100 → 389
    PHA02782; hypothetical protein; Provisional

RNA

  1. XR_005490382.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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