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Pramef8l3 PRAME family member 8 like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501893, updated on 3-Apr-2024

Summary

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Official Symbol
Pramef8l3provided by RGD
Official Full Name
PRAME family member 8 like 3provided by RGD
Primary source
RGD:1562932
See related
Ensembl:ENSRNOG00000063749 AllianceGenome:RGD:1562932
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562932
Summary
Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
14p22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (14762871..14765506)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (14458467..14461102)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (523690..526463)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene PRAME family member 8-like Neighboring gene putative PRAME family member 24-like Neighboring gene protein NYNRIN-like Neighboring gene PRAME family member 8-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PRAME family member 8
Names
PRAME family member 8-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    14762871..14765506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003751305.3 → XP_003751353.2  PRAME family member 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHD7, A0A8I6GK57
    Related
    ENSRNOP00000092394.1, ENSRNOT00000118022.1
    Conserved Domains (1) summary
    cl26877
    Location:322 → 433
    Band_3_cyto; Band 3 cytoplasmic domain

  2. XM_017599559.2 → XP_017455048.2  PRAME family member 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AHD7
    Conserved Domains (1) summary
    cl26877
    Location:321 → 432
    Band_3_cyto; Band 3 cytoplasmic domain

  3. XM_017599560.2 → XP_017455049.2  PRAME family member 8 isoform X3

    Conserved Domains (1) summary
    cl26877
    Location:124 → 235
    Band_3_cyto; Band 3 cytoplasmic domain
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases