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Mettl8 methyltransferase 8, tRNA N3-cytidine [ Rattus norvegicus (Norway rat) ]

Gene ID: 502633, updated on 6-Jun-2024

Summary

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Official Symbol
Mettl8provided by RGD
Official Full Name
methyltransferase 8, tRNA N3-cytidineprovided by RGD
Primary source
RGD:1561059
See related
Ensembl:ENSRNOG00000009382 AllianceGenome:RGD:1561059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561059; AABR07052486.1
Summary
Predicted to enable histone acetyltransferase activity and mRNA methyltransferase activity. Predicted to be involved in mRNA methylation. Predicted to act upstream of or within fat cell differentiation; histone acetylation; and skeletal muscle tissue development. Predicted to be located in cytoplasm and nucleus. Orthologous to human METTL8 (methyltransferase 8, methylcytidine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 39.2), Lung (RPKM 22.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mettl8 in Genome Data Viewer
Location:
3q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76140465..76271367, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55731453..55863652, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57257394..57642096, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486287 Neighboring gene ribosomal protein L15 like 2 Neighboring gene uncharacterized LOC134486104 Neighboring gene uncharacterized LOC134486103 Neighboring gene DDB1 and CUL4 associated factor 17 Neighboring gene cytochrome b reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation. Jakkaraju S, et al. Dev Cell, 2005 Jul. PMID 15992539
  2. Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, et al. J Biol Chem, 2017 Sep 1. PMID 28655767, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables mRNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (cytidine-3-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA C3-cytosine methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
NOT is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial
Names
mRNA N(3)-methylcytidine methyltransferase METTL8
methyltransferase 8, methylcytidine
methyltransferase like 8
methyltransferase-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399513.1 → NP_001386442.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM36, A6HM37
    Related
    ENSRNOP00000067958.2, ENSRNOT00000075860.2
    Conserved Domains (1) summary
    pfam13649
    Location:190 → 293
    Methyltransf_25; Methyltransferase domain

  2. NM_001399514.1 → NP_001386443.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    76140465..76271367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284403.1 → XP_063140473.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X4

  2. XM_039106364.2 → XP_038962292.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam13649
    Location:202 → 305
    Methyltransf_25; Methyltransferase domain

  3. XM_008761954.4 → XP_008760176.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_008760176.1

    UniProtKB/TrEMBL
    A6HM36, D3ZFN6
    Related
    ENSRNOP00000055322.5
    Conserved Domains (2) summary
    COG0500
    Location:197 → 392
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:203 → 307
    Methyltransf_12; Methyltransferase domain

  4. XM_039106365.2 → XP_038962293.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6HM36
    Conserved Domains (1) summary
    pfam13649
    Location:165 → 268
    Methyltransf_25; Methyltransferase domain

  5. XM_063284404.1 → XP_063140474.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X5

    UniProtKB/TrEMBL
    A0A096MK97

RNA

  1. XR_005502190.2 RNA Sequence

  2. XR_005502191.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
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