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Scrn1 secernin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502776, updated on 5-Mar-2024

Summary

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Symbol
Scrn1provided by RGD
Full Name
secernin 1provided by RGD
Primary source
RGD:1560999
See related
Ensembl:ENSRNOG00000009636 AllianceGenome:RGD:1560999
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in exocytosis and proteolysis. Predicted to be located in nuclear membrane. Orthologous to human SCRN1 (secernin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 361.7), Uterus (RPKM 45.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scrn1 in Genome Data Viewer
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84962450..85024577, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83632125..83694225, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84678978..84740701, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 1 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene uncharacterized LOC102553885 Neighboring gene FKBP prolyl isomerase 14 Neighboring gene pleckstrin homology domain containing A8 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. VAP-SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function. Lindhout FW, et al. EMBO J, 2019 Oct 15. PMID 31441084, Free PMC Article
  2. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secernin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025063.1 → NP_001020234.1  secernin-1

    See identical proteins and their annotated locations for NP_001020234.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079152
    UniProtKB/Swiss-Prot
    Q6AY84
    UniProtKB/TrEMBL
    A6K0V2
    Conserved Domains (1) summary
    cl00467
    Location:18 → 227
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    84962450..85024577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108254.2 → XP_038964182.1  secernin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY84
    UniProtKB/TrEMBL
    A6K0V2
    Related
    ENSRNOP00000013088.3
    Conserved Domains (1) summary
    cl00467
    Location:18 → 227
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  2. XM_006236512.5 → XP_006236574.1  secernin-1 isoform X1

    See identical proteins and their annotated locations for XP_006236574.1

    UniProtKB/Swiss-Prot
    Q6AY84
    UniProtKB/TrEMBL
    A6K0V2
    Conserved Domains (1) summary
    cl00467
    Location:18 → 227
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  3. XM_063286615.1 → XP_063142685.1  secernin-1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY84.1 GenPept UniProtKB/Swiss-Prot:Q6AY84

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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