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Defa24 defensin, alpha, 24 [ Mus musculus (house mouse) ]

Gene ID: 503491, updated on 23-Jun-2021

Summary

Official Symbol
Defa24provided by MGI
Official Full Name
defensin, alpha, 24provided by MGI
Primary source
MGI:MGI:3630383
See related
Ensembl:ENSMUSG00000064213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Defcr2; Defcr24
Expression
Biased expression in large intestine adult (RPKM 2557.7), small intestine adult (RPKM 759.5) and 1 other tissue See more
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Genomic context

See Defa24 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22224510..22225487)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21734494..21735471)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (22844966..22845943)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MYM-type 5 pseudogene Neighboring gene defensin, alpha, pseudogene 10 Neighboring gene defensin, alpha, pseudogene 11 Neighboring gene defensin beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in killing by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
 
involved_in killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane disruption in other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of membrane permeability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-defensin 24
Names
defensin-related cryptdin-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024225.2NP_001019396.1  alpha-defensin 24 precursor

    See identical proteins and their annotated locations for NP_001019396.1

    Status: VALIDATED

    Source sequence(s)
    AC134533, AY746429
    Consensus CDS
    CCDS40281.1
    UniProtKB/Swiss-Prot
    Q5G865
    Related
    ENSMUSP00000079376.6, ENSMUST00000080533.6
    Conserved Domains (2) summary
    pfam00323
    Location:6492
    Defensin_1; Mammalian defensin
    pfam00879
    Location:1451
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22224510..22225487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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