apobec2a apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: apobec2aprovided by ZNC
Official Full Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050306-15
See related: Ensembl:ENSDARG00000018881 AllianceGenome:ZFIN:ZDB-GENE-050306-15
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110762
Summary: Predicted to enable RNA binding activity and cytidine deaminase activity. Acts upstream of or within several processes, including cell dedifferentiation; heart looping; and sensory epithelium regeneration. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adaxial cell; axial hypoblast; cardiovascular system; musculature system; and retina. Orthologous to human APOBEC2 (apolipoprotein B mRNA editing enzyme catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (641346..651678, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (603623..613955, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data of this study demonistrated that the apobec2a is essential for retina and optic nerve regeneration.
Title: Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cytidine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA demethylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell dedifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytidine to uridine editing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: C->U-editing enzyme APOBEC-2a

Names: apo2a; apolipoprotein B-editing catalytic subunit 2a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013314.2 → NP_001013332.1 C->U-editing enzyme APOBEC-2a

See identical proteins and their annotated locations for NP_001013332.1

Status: PROVISIONAL

Source sequence(s)

BC090758

UniProtKB/TrEMBL

Q5CZQ2

Related

ENSDARP00000124325.1, ENSDART00000148692.2

Conserved Domains (3) summary

cd01283
Location:93 → 170

cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...

pfam05240
Location:188 → 233

APOBEC_C; APOBEC-like C-terminal domain

pfam08210
Location:84 → 246

APOBEC_N; APOBEC-like N-terminal domain