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Tmprss2 transmembrane protease, serine 2 [ Mus musculus (house mouse) ]

Gene ID: 50528, updated on 21-Apr-2024

Summary

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Official Symbol
Tmprss2provided by MGI
Official Full Name
transmembrane protease, serine 2provided by MGI
Primary source
MGI:MGI:1354381
See related
Ensembl:ENSMUSG00000000385 AllianceGenome:MGI:1354381
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D16Ertd61e
Summary
Predicted to enable scavenger receptor activity and serine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; liver and biliary system; and respiratory system. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 149.8), colon adult (RPKM 109.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C4; 16 57.53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97365882..97460741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97564682..97659541, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene STARR-seq mESC enhancer starr_41630 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41631 Neighboring gene STARR-seq mESC enhancer starr_41632 Neighboring gene MX dynamin-like GTPase 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:97814757-97815058 Neighboring gene STARR-seq mESC enhancer starr_41635 Neighboring gene predicted gene, 41512 Neighboring gene predicted gene, 41513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection. Metzdorf K, et al. Viruses, 2023 Jan 18. PMID 36851486, Free PMC Article
  2. Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions. Li X, et al. Nat Commun, 2022 Jul 26. PMID 35882856, Free PMC Article
  3. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2. Vo T, et al. Sci Rep, 2022 Jan 25. PMID 35079032, Free PMC Article
  4. H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice. Lambertz RLO, et al. Virol J, 2020 Apr 22. PMID 32321537, Free PMC Article
  5. Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis. Lambertz RLO, et al. J Gen Virol, 2019 Jul. PMID 31099738

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport.
    Title: Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport.
  2. Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion.
    Title: Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion.
  3. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection.
    Title: TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection.
  4. Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways.
    Title: Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways.
  5. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.
    Title: Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.
  6. Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury.
    Title: Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury.
  7. EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
    Title: EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
  8. Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.
    Title: Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.
  9. Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung.
    Title: Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung.
  10. Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19.
    Title: Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (10) 

General gene information

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Markers

Homology

Clone Names

  • MGC6821

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoprocessing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protease serine 2
Names
epitheliasin
plasmic transmembrane protein X
NP_056590.2
XP_006523127.1
XP_006523128.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015775.2 → NP_056590.2  transmembrane protease serine 2

    See identical proteins and their annotated locations for NP_056590.2

    Status: PROVISIONAL

    Source sequence(s)
    BC054348
    Consensus CDS
    CCDS37417.1
    UniProtKB/Swiss-Prot
    Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
    UniProtKB/TrEMBL
    Q3UKE3
    Related
    ENSMUSP00000000395.7, ENSMUST00000000395.8
    Conserved Domains (3) summary
    cd00112
    Location:112 → 147
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:152 → 247
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    97365882..97460741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523064.3 → XP_006523127.1  transmembrane protease serine 2 isoform X1

    See identical proteins and their annotated locations for XP_006523127.1

    UniProtKB/Swiss-Prot
    Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
    UniProtKB/TrEMBL
    Q3UKE3
    Conserved Domains (3) summary
    cd00112
    Location:112 → 147
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:152 → 247
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_006523065.2 → XP_006523128.1  transmembrane protease serine 2 isoform X1

    See identical proteins and their annotated locations for XP_006523128.1

    UniProtKB/Swiss-Prot
    Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
    UniProtKB/TrEMBL
    Q3UKE3
    Conserved Domains (3) summary
    cd00112
    Location:112 → 147
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:152 → 247
    SRCR_2; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIQ8.3 GenPept UniProtKB/Swiss-Prot:Q9JIQ8

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