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Postn periostin, osteoblast specific factor [ Mus musculus (house mouse) ]

Gene ID: 50706, updated on 2-Oct-2021

Summary

Official Symbol
Postnprovided by MGI
Official Full Name
periostin, osteoblast specific factorprovided by MGI
Primary source
MGI:MGI:1926321
See related
Ensembl:ENSMUSG00000027750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Os; PN; Pe; OSF; PLF; Osf2; OSF-2; AI747096; A630052E07Rik
Summary
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Biased expression in limb E14.5 (RPKM 151.8), placenta adult (RPKM 112.7) and 12 other tissues See more
Orthologs
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Genomic context

See Postn in Genome Data Viewer
Location:
3; 3 C
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54266688..54298462)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (54359267..54391041)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (54165047..54194954)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 Neighboring gene predicted gene, 54174 Neighboring gene predicted gene, 31095 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 31154

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vitamin K IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vitamin K ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
periostin
Names
osteoblast specific factor 2 (fasciclin I-like)
osteoblast-specific factor 2
periostin-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198765.1NP_001185694.1  periostin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001185694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC139043, AK030756, BE850247, BF020820
    Consensus CDS
    CCDS57211.1
    UniProtKB/Swiss-Prot
    Q62009
    Related
    ENSMUSP00000103619.4, ENSMUST00000107985.10
    Conserved Domains (1) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
  2. NM_001198766.1NP_001185695.1  periostin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001185695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC139043
    Consensus CDS
    CCDS57212.1
    UniProtKB/Swiss-Prot
    Q62009
    Related
    ENSMUSP00000112735.2, ENSMUST00000117373.8
    Conserved Domains (1) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
  3. NM_001313898.1NP_001300827.1  periostin isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame exon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC139043
    UniProtKB/TrEMBL
    A0A097BW21
    Conserved Domains (1) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
  4. NM_001313899.1NP_001300828.1  periostin isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AC139043
    UniProtKB/TrEMBL
    A0A097BW18
    Conserved Domains (1) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
  5. NM_001368678.1NP_001355607.1  periostin isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR and two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 6, which is longer than isoform 1.
    Source sequence(s)
    AC117594, AC139043
    Consensus CDS
    CCDS89624.1
    Related
    ENSMUSP00000080276.7, ENSMUST00000081564.13
    Conserved Domains (1) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
  6. NM_015784.3NP_056599.1  periostin isoform 1 precursor

    See identical proteins and their annotated locations for NP_056599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC139043, BE850247, BF020820, D13664
    Consensus CDS
    CCDS17351.1
    UniProtKB/Swiss-Prot
    Q62009
    Related
    ENSMUSP00000072773.7, ENSMUST00000073012.13
    Conserved Domains (1) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    54266688..54298462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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