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SHC1 SHC adaptor protein 1 [ Bos taurus (cattle) ]

Gene ID: 507196, updated on 11-Apr-2024

Summary

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Official Symbol
SHC1provided by VGNC
Official Full Name
SHC adaptor protein 1provided by VGNC
Primary source
VGNC:VGNC:34590
See related
BGD:BT18799; Ensembl:ENSBTAG00000019838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
p66shc
Orthologs
human mouse all
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Genomic context

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See SHC1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (15616404..15626916)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene lens epithelial protein Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene uncharacterized LOC132344832 Neighboring gene pygopus family PHD finger 2 Neighboring gene PBX homeobox interacting protein 1 Neighboring gene small nucleolar RNA SNORA51

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE). Streese L, et al. Eur Heart J, 2020 Apr 14. PMID 31323685
  2. The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. Betts DH, et al. PLoS One, 2014. PMID 24475205, Free PMC Article
  3. Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos. Bain NT, et al. Mol Reprod Dev, 2013 Jan. PMID 23109234
  4. The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro. Favetta LA, et al. BMC Dev Biol, 2007 Nov 29. PMID 18047664, Free PMC Article
  5. High levels of p66shc and intracellular ROS in permanently arrested early embryos. Favetta LA, et al. Free Radic Biol Med, 2007 Apr 15. PMID 17382201

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE).
    Title: High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE).
  2. The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos.
    Title: The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos.
  3. Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase.
    Title: Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos.
  4. These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.
    Title: Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation.
  5. p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos
    Title: The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro.
  6. p66shc, but not p53, is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.
    Title: High levels of p66shc and intracellular ROS in permanently arrested early embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SHC-transforming protein 1
Names
SH2 domain protein C1
SHC (Src homology 2 domain containing) transforming protein 1
src homology 2 domain-containing-transforming protein C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075305.2 → NP_001068773.1  SHC-transforming protein 1 isoform b

    See identical proteins and their annotated locations for NP_001068773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    BC122688, EH179100, EV724133
    UniProtKB/Swiss-Prot
    Q0IIE2, Q45KX9
    Conserved Domains (3) summary
    cd09925
    Location:370 → 473
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36 → 207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    cl26386
    Location:264 → 400
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  2. NM_001164061.1 → NP_001157533.1  SHC-transforming protein 1 isoform a

    See identical proteins and their annotated locations for NP_001157533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC122688, EE957359, EV724133
    UniProtKB/TrEMBL
    E1B716
    Conserved Domains (2) summary
    cd09925
    Location:480 → 583
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146 → 317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    15616404..15626916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059882857.1 → XP_059738840.1  SHC-transforming protein 1 isoform X1

  2. XM_059882853.1 → XP_059738836.1  SHC-transforming protein 1 isoform X1

  3. XM_059882861.1 → XP_059738844.1  SHC-transforming protein 1 isoform X2

    Related
    ENSBTAP00000040041.4, ENSBTAT00000040264.5

  4. XM_059882865.1 → XP_059738848.1  SHC-transforming protein 1 isoform X3

    Related
    ENSBTAP00000026432.5, ENSBTAT00000026432.6

  5. XM_059882866.1 → XP_059738849.1  SHC-transforming protein 1 isoform X4

    UniProtKB/TrEMBL
    E1B716

  6. XM_005203675.5 → XP_005203732.1  SHC-transforming protein 1 isoform X6

    See identical proteins and their annotated locations for XP_005203732.1

    Conserved Domains (2) summary
    cd09925
    Location:389 → 492
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36 → 225
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  7. XM_005203673.5 → XP_005203730.1  SHC-transforming protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005203730.1

    Conserved Domains (2) summary
    cd09925
    Location:392 → 495
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:39 → 228
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  8. XM_024986715.2 → XP_024842483.1  SHC-transforming protein 1 isoform X7

    Conserved Domains (3) summary
    cd09925
    Location:374 → 477
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:39 → 210
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    cl26386
    Location:267 → 397
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  9. XM_024986719.2 → XP_024842487.1  SHC-transforming protein 1 isoform X8

    Related
    ENSBTAP00000062285.2, ENSBTAT00000075224.2
    Conserved Domains (3) summary
    cd09925
    Location:373 → 476
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:39 → 210
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    cl26386
    Location:267 → 396
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0IIE2.1 GenPept UniProtKB/Swiss-Prot:Q0IIE2

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