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Icosl icos ligand [ Mus musculus (house mouse) ]

Gene ID: 50723, updated on 2-Oct-2021

Summary

Official Symbol
Icoslprovided by MGI
Official Full Name
icos ligandprovided by MGI
Primary source
MGI:MGI:1354701
See related
Ensembl:ENSMUSG00000000732
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IC; B7h; GL5; B7RP; GI50; GL50; B7-H2; GL50-; LICOS; B7RP-1; GL50-B; ICOS-L; Icoslg; Ly115l; AU044799; BG071784; mKIAA0653
Expression
Broad expression in spleen adult (RPKM 32.9), mammary gland adult (RPKM 16.0) and 17 other tissues See more
Orthologs
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Genomic context

See Icosl in Genome Data Viewer
Location:
10; 10 C1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77904921..77915359)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78069368..78079525)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (77532113..77542270)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphofructokinase, liver, B-type Neighboring gene autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Neighboring gene DNA (cytosine-5-)-methyltransferase 3-like Neighboring gene predicted gene, 51775 Neighboring gene predicted gene, 47922 Neighboring gene glutamine amidotransferase like class 1 domain containing 3A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0653

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in isotype switching NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of activated T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ICOS ligand
Names
B7 homolog 2
B7-like protein Gl50
B7-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015790.3NP_056605.1  ICOS ligand precursor

    See identical proteins and their annotated locations for NP_056605.1

    Status: PROVISIONAL

    Source sequence(s)
    AC153507
    Consensus CDS
    CCDS35956.1
    UniProtKB/Swiss-Prot
    Q9JHJ8
    UniProtKB/TrEMBL
    Q544C7
    Related
    ENSMUSP00000101032.2, ENSMUST00000105393.3
    Conserved Domains (2) summary
    smart00410
    Location:52140
    IG_like; Immunoglobulin like
    cl11960
    Location:166253
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    77904921..77915359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155889.1XP_036011782.1  ICOS ligand isoform X1

    Conserved Domains (3) summary
    cd00096
    Location:256263
    Ig; Ig strand B [structural motif]
    cd20935
    Location:123236
    IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)
    cl11960
    Location:241328
    Ig; Immunoglobulin domain
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