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Icosl icos ligand [ Mus musculus (house mouse) ]

Gene ID: 50723, updated on 5-Mar-2024

Summary

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Official Symbol
Icoslprovided by MGI
Official Full Name
icos ligandprovided by MGI
Primary source
MGI:MGI:1354701
See related
Ensembl:ENSMUSG00000000732 AllianceGenome:MGI:1354701
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B7h; GI50; GL50; B7-H2; LICOS; B7RP-1; GL50-B; ICOS-L; Icoslg; Ly115l; mKIAA0653
Summary
Predicted to enable identical protein binding activity and signaling receptor binding activity. Involved in positive regulation of interleukin-4 production. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including extraembryonic component; gonad; hemolymphoid system gland; liver; and stomach. Orthologous to human ICOSLG (inducible T cell costimulator ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 32.9), mammary gland adult (RPKM 16.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Icosl in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77904921..77915359)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78069368..78079525)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphofructokinase, liver, B-type Neighboring gene STARR-positive B cell enhancer ABC_E5151 Neighboring gene STARR-seq mESC enhancer starr_27212 Neighboring gene STARR-seq mESC enhancer starr_27213 Neighboring gene STARR-seq mESC enhancer starr_27214 Neighboring gene STARR-seq mESC enhancer starr_27215 Neighboring gene autoimmune regulator Neighboring gene DNA methyltransferase 3-like Neighboring gene predicted gene, 51775 Neighboring gene STARR-positive B cell enhancer ABC_E5152 Neighboring gene STARR-positive B cell enhancer ABC_E6876 Neighboring gene STARR-positive B cell enhancer ABC_E2328 Neighboring gene predicted gene, 47922 Neighboring gene glutamine amidotransferase like class 1 domain containing 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ICOSL(+) plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist. Adom D, et al. Sci Transl Med, 2020 Oct 7. PMID 33028709, Free PMC Article
  2. Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist. Koh KH, et al. J Clin Invest, 2019 Apr 1. PMID 30747722, Free PMC Article
  3. Th17 down-regulation is involved in reduced progression of schistosomiasis fibrosis in ICOSL KO mice. Wang B, et al. PLoS Negl Trop Dis, 2015 Jan. PMID 25590646, Free PMC Article
  4. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Liu D, et al. Nature, 2015 Jan 8. PMID 25317561
  5. Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. Chen X, et al. PLoS Pathog, 2014 May. PMID 24788758, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
    Title: A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
  2. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
    Title: Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
  3. Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
    Title: Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation.
  4. ICOS ligand and IL-10 synergize to promote host-microbiota mutualism.
    Title: ICOS ligand and IL-10 synergize to promote host-microbiota mutualism.
  5. work identified a potentially novel role for ICOSL, which serves as an endogenous alphavbeta3-selective antagonist to maintain glomerular filtration.
    Title: Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist.
  6. study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels
    Title: ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
  7. results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h during their differentiation, and that B7h triggering reversibly inhibits OC differentiation and function both in vitro and in vivo
    Title: ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo.
  8. study concludse that lymphopenia-driven autoimmunity and the development of Tfh17 cells in Rasgrp1-deficient mice occur independently of CD275(B7-H2)
    Title: CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice.
  9. The expression of ICOSL in the cornea and the ICOS-mediated induction of Foxp3+ CD4+ regulatory T cells may contribute to successful corneal allograft survival.
    Title: Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.
  10. this study shows that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase inhibitor (MMPI) could suppress sICOSL production
    Title: Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0653

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in isotype switching NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of activated T cell proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ICOS ligand
Names
B7 homolog 2
B7-like protein Gl50
B7-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015790.3 → NP_056605.1  ICOS ligand precursor

    See identical proteins and their annotated locations for NP_056605.1

    Status: PROVISIONAL

    Source sequence(s)
    AC153507
    Consensus CDS
    CCDS35956.1
    UniProtKB/Swiss-Prot
    Q9JHJ8
    UniProtKB/TrEMBL
    A0A1W2P6Q2, Q544C7
    Related
    ENSMUSP00000101032.2, ENSMUST00000105393.3
    Conserved Domains (2) summary
    smart00410
    Location:52 → 140
    IG_like; Immunoglobulin like
    cl11960
    Location:166 → 253
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    77904921..77915359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155889.1 → XP_036011782.1  ICOS ligand isoform X1

    Conserved Domains (3) summary
    cd00096
    Location:256 → 263
    Ig; Ig strand B [structural motif]
    cd20935
    Location:123 → 236
    IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)
    cl11960
    Location:241 → 328
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHJ8.1 GenPept UniProtKB/Swiss-Prot:Q9JHJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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