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Atp11a ATPase, class VI, type 11A [ Mus musculus (house mouse) ]

Gene ID: 50770, updated on 11-Apr-2024

Summary

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Official Symbol
Atp11aprovided by MGI
Official Full Name
ATPase, class VI, type 11Aprovided by MGI
Primary source
MGI:MGI:1354735
See related
Ensembl:ENSMUSG00000031441 AllianceGenome:MGI:1354735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ih; Atpc1h; 4930558F19Rik
Summary
Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Involved in positive regulation of myotube differentiation. Acts upstream of or within in utero embryonic development. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Orthologous to human ATP11A (ATPase phospholipid transporting 11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 80.2), kidney adult (RPKM 45.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Atp11a in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (12807016..12918728)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (12757016..12868728)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20748 Neighboring gene predicted gene, 39133 Neighboring gene predicted gene, 33587 Neighboring gene predicted gene 15350 Neighboring gene predicted gene 15353 Neighboring gene mcf.2 transforming sequence-like Neighboring gene predicted gene 15351

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a. Zhang B, et al. Blood, 2005 Aug 15. PMID 15860663, Free PMC Article
  2. Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes. Miyata Y, et al. J Biol Chem, 2022 Nov. PMID 36162506, Free PMC Article
  3. Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta. Ochiai Y, et al. Proc Natl Acad Sci U S A, 2022 May 3. PMID 35476530, Free PMC Article
  4. A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes. Segawa K, et al. J Clin Invest, 2021 Sep 15. PMID 34403372, Free PMC Article
  5. A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2. Chepurwar S, et al. Hum Mol Genet, 2023 Mar 20. PMID 36300302

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2.
    Title: A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2.
  2. Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes.
    Title: Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes.
  3. Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta.
    Title: Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta.
  4. A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.
    Title: A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.
  5. ATP11A and ATP11C in precursor B cells are essential for rapidly internalizing PtdSer from the cell surface to prevent the cells' engulfment by macrophages.
    Title: Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.
  6. results show that elevated levels of ATP11a can protect malignant lymphoblastic leukemia cells against several novel small molecule signal transduction inhibitors
    Title: Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane lipid distribution ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase IH
Names
9130422H11Rik
ATPase 11A, class VI
ATPase 11A, p type
ATPase, class 1, member h
P4-ATPase flippase complex alpha subunit ATP11A
probable phospholipid-transporting ATPase IH
NP_001280596.1
NP_001280597.1
NP_056619.1
XP_006508897.1
XP_006508900.1
XP_006508902.1
XP_006508903.1
XP_011240369.1
XP_017168382.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293667.1 → NP_001280596.1  phospholipid-transporting ATPase IH isoform 2

    See identical proteins and their annotated locations for NP_001280596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC134581, AK147497
    Consensus CDS
    CCDS80858.1
    UniProtKB/TrEMBL
    E9Q3G7, Q69ZT0
    Related
    ENSMUSP00000033818.4, ENSMUST00000033818.10
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. NM_001293668.1 → NP_001280597.1  phospholipid-transporting ATPase IH isoform 3

    See identical proteins and their annotated locations for NP_001280597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC134581, AK147497, BC145399
    UniProtKB/TrEMBL
    Q69ZT0
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  3. NM_015804.3 → NP_056619.1  phospholipid-transporting ATPase IH isoform 1

    See identical proteins and their annotated locations for NP_056619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC134581, AK147497, CF167530
    Consensus CDS
    CCDS40223.1
    UniProtKB/Swiss-Prot
    B2RS49, P98197
    UniProtKB/TrEMBL
    Q69ZT0
    Related
    ENSMUSP00000088779.6, ENSMUST00000091237.12
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RNA

  1. NR_121603.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC134581, AK147497, BC145400

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    12807016..12918728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508839.5 → XP_006508902.1  phospholipid-transporting ATPase IH isoform X3

    See identical proteins and their annotated locations for XP_006508902.1

    UniProtKB/TrEMBL
    Q69ZT0
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. XM_006508837.3 → XP_006508900.1  phospholipid-transporting ATPase IH isoform X2

    UniProtKB/TrEMBL
    Q69ZT0
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  3. XM_006508834.3 → XP_006508897.1  phospholipid-transporting ATPase IH isoform X1

    See identical proteins and their annotated locations for XP_006508897.1

    UniProtKB/TrEMBL
    E9Q3G7, Q69ZT0
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  4. XM_011242067.2 → XP_011240369.1  phospholipid-transporting ATPase IH isoform X1

    See identical proteins and their annotated locations for XP_011240369.1

    UniProtKB/TrEMBL
    E9Q3G7, Q69ZT0
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  5. XM_017312893.1 → XP_017168382.1  phospholipid-transporting ATPase IH isoform X3

    UniProtKB/TrEMBL
    Q69ZT0
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  6. XM_006508840.3 → XP_006508903.1  phospholipid-transporting ATPase IH isoform X4

    UniProtKB/TrEMBL
    Q69ZT0
    Conserved Domains (1) summary
    cd02073
    Location:47 → 986
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RNA

  1. XR_004934861.1 RNA Sequence

  2. XR_004934860.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98197.1 GenPept UniProtKB/Swiss-Prot:P98197

Gene LinkOut

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