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Rgs3 regulator of G-protein signaling 3 [ Mus musculus (house mouse) ]

Gene ID: 50780, updated on 5-Mar-2024

Summary

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Official Symbol
Rgs3provided by MGI
Official Full Name
regulator of G-protein signaling 3provided by MGI
Primary source
MGI:MGI:1354734
See related
Ensembl:ENSMUSG00000059810 AllianceGenome:MGI:1354734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C2pa; RGS3S; PDZ-RGS3; C2PA-RGS3; 4930506N09Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; lung; and nervous system. Orthologous to human RGS3 (regulator of G protein signaling 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 8.2), ovary adult (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B3; 4 33.19 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62478079..62621256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62559835..62703019)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933430I17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62186055-62186242 Neighboring gene polymerase (DNA directed), epsilon 3 (p17 subunit) Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62213110-62213293 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62222257-62222558 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62322547-62322847 Neighboring gene STARR-seq mESC enhancer starr_10430 Neighboring gene predicted gene, 52741 Neighboring gene STARR-seq mESC enhancer starr_10432 Neighboring gene predicted gene 11210 Neighboring gene predicted gene 11211 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62417671-62417854 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62418020-62418129 Neighboring gene predicted gene, 30699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spindle Orientation-Independent Control of Cell Fate Determination by RGS3 and KIF20A. Qiu R, et al. Cereb Cortex Commun, 2020. PMID 32864611, Free PMC Article
  2. RGS3 inhibits TGF-β1/Smad signalling in adventitial fibroblasts. Xu F, et al. Cell Biochem Funct, 2017 Aug. PMID 28845525
  3. RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. Williams JW, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Nov 15. PMID 24077945, Free PMC Article
  4. C2PA is a nuclear protein implicated in the heat shock response. Hirabayashi S, et al. J Cell Biochem, 2002. PMID 12210723
  5. Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3. Kehrl JH, et al. Genomics, 2002 Jun. PMID 12036301

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 3
Names
C2 membrane binding, PDZ protein/protein interaction, ATP/GTP binding domains

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081650.2 → NP_001075119.1  regulator of G-protein signaling 3 isoform 3

    See identical proteins and their annotated locations for NP_001075119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AK028445, BB653029, BB739116
    Consensus CDS
    CCDS38776.1
    UniProtKB/Swiss-Prot
    Q9DC04
    Related
    ENSMUSP00000103047.2, ENSMUST00000107424.2
    Conserved Domains (2) summary
    COG0265
    Location:38 → 93
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:17 → 91
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001310706.1 → NP_001297635.1  regulator of G-protein signaling 3 isoform 4

    See identical proteins and their annotated locations for NP_001297635.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and lacks multiple exons in the 5' coding region. These differences cause translation initiation at a downstream start codon compared to variant 2. It encodes isoform 4, which has a significantly shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    AK004648, AL672272, BE686796, CF738041
    Consensus CDS
    CCDS80110.1
    UniProtKB/Swiss-Prot
    Q9DC04
    Related
    ENSMUSP00000103043.2, ENSMUST00000107420.8
    Conserved Domains (2) summary
    cd08713
    Location:444 → 557
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:3 → 226
    PHA03307; transcriptional regulator ICP4; Provisional

  3. NM_019492.3 → NP_062365.2  regulator of G-protein signaling 3 isoform 1

    See identical proteins and their annotated locations for NP_062365.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' exon structure compared to variant 2. It encodes isoform 1 which is shorter and has distinct N- and C-termini, compared to isoform 2.
    Source sequence(s)
    AK015722, AK028445, AL672272, BB739116
    Consensus CDS
    CCDS18246.1
    UniProtKB/TrEMBL
    Z4YJQ4
    Related
    ENSMUSP00000065447.8, ENSMUST00000065870.14
    Conserved Domains (2) summary
    cd08685
    Location:35 → 154
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd00992
    Location:195 → 268
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  4. NM_134257.3 → NP_599018.3  regulator of G-protein signaling 3 isoform 2

    See identical proteins and their annotated locations for NP_599018.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AF319519, AF350047, AK004648, BE686796
    Consensus CDS
    CCDS51202.1
    UniProtKB/Swiss-Prot
    Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9DC04, Q9JL22, Q9JL23, Q9QXA2
    Related
    ENSMUSP00000081569.5, ENSMUST00000084521.11
    Conserved Domains (5) summary
    cd08713
    Location:842 → 955
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    COG0265
    Location:38 → 93
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:17 → 91
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15231
    Location:428 → 572
    VCX_VCY; Variable charge X/Y family
    pfam15265
    Location:438 → 592
    FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62478079..62621256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538057.4 → XP_006538120.1  regulator of G-protein signaling 3 isoform X1

    Conserved Domains (4) summary
    cd08685
    Location:35 → 154
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd08713
    Location:1019 → 1132
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:578 → 801
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:195 → 268
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. XM_011250065.4 → XP_011248367.1  regulator of G-protein signaling 3 isoform X6

    Conserved Domains (2) summary
    cd08685
    Location:35 → 154
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd00992
    Location:195 → 268
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. XM_036164227.1 → XP_036020120.1  regulator of G-protein signaling 3 isoform X5

    UniProtKB/TrEMBL
    Z4YJQ4
    Conserved Domains (2) summary
    cd08685
    Location:35 → 154
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd00992
    Location:195 → 268
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  4. XM_030253652.2 → XP_030109512.1  regulator of G-protein signaling 3 isoform X9

    UniProtKB/TrEMBL
    I7HPB2
    Related
    ENSMUSP00000095639.4, ENSMUST00000098031.10
    Conserved Domains (2) summary
    cd08685
    Location:27 → 146
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd00992
    Location:187 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  5. XM_006538058.5 → XP_006538121.1  regulator of G-protein signaling 3 isoform X2

    Conserved Domains (4) summary
    cd08685
    Location:27 → 146
    C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
    cd08713
    Location:1011 → 1124
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:570 → 793
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:187 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_006538060.3 → XP_006538123.1  regulator of G-protein signaling 3 isoform X3

    Conserved Domains (4) summary
    cd08713
    Location:961 → 1074
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:520 → 743
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:137 → 210
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14603
    Location:1 → 96
    C2; C2 domain

  7. XM_036164226.1 → XP_036020119.1  regulator of G-protein signaling 3 isoform X4

    Conserved Domains (3) summary
    cd08713
    Location:844 → 957
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:403 → 626
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:20 → 93
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  8. XM_006538068.5 → XP_006538131.1  regulator of G-protein signaling 3 isoform X10

    See identical proteins and their annotated locations for XP_006538131.1

    UniProtKB/Swiss-Prot
    Q9DC04
    Conserved Domains (2) summary
    cd08713
    Location:444 → 557
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:3 → 226
    PHA03307; transcriptional regulator ICP4; Provisional

  9. XM_006538070.4 → XP_006538133.1  regulator of G-protein signaling 3 isoform X10

    See identical proteins and their annotated locations for XP_006538133.1

    UniProtKB/Swiss-Prot
    Q9DC04
    Conserved Domains (2) summary
    cd08713
    Location:444 → 557
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:3 → 226
    PHA03307; transcriptional regulator ICP4; Provisional

  10. XM_006538069.3 → XP_006538132.1  regulator of G-protein signaling 3 isoform X10

    See identical proteins and their annotated locations for XP_006538132.1

    UniProtKB/Swiss-Prot
    Q9DC04
    Conserved Domains (2) summary
    cd08713
    Location:444 → 557
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:3 → 226
    PHA03307; transcriptional regulator ICP4; Provisional

  11. XM_006538067.4 → XP_006538130.2  regulator of G-protein signaling 3 isoform X7

    Conserved Domains (2) summary
    cd08713
    Location:534 → 647
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:93 → 316
    PHA03307; transcriptional regulator ICP4; Provisional

  12. XM_036164228.1 → XP_036020121.1  regulator of G-protein signaling 3 isoform X8

    Conserved Domains (2) summary
    cd08713
    Location:486 → 599
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    PHA03307
    Location:45 → 268
    PHA03307; transcriptional regulator ICP4; Provisional

  13. XM_017320308.3 → XP_017175797.1  regulator of G-protein signaling 3 isoform X11

    UniProtKB/TrEMBL
    Q542M0
    Related
    ENSMUSP00000159172.2, ENSMUST00000125369.8
    Conserved Domains (1) summary
    cd08713
    Location:68 → 181
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

  14. XM_006538072.4 → XP_006538135.1  regulator of G-protein signaling 3 isoform X12

    See identical proteins and their annotated locations for XP_006538135.1

    UniProtKB/TrEMBL
    Q3TAS0
    Conserved Domains (1) summary
    cd08713
    Location:44 → 157
    RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC04.2 GenPept UniProtKB/Swiss-Prot:Q9DC04

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