TAS2R8 taste 2 receptor member 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R8provided by HGNC
Official Full Name: taste 2 receptor member 8provided by HGNC
Primary source: HGNC:HGNC:14915
See related: Ensembl:ENSG00000121314 MIM:604794; AllianceGenome:HGNC:14915
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2R8; TRB5
Summary: This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: 12p13.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (10806051..10807286, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (10679133..10680368, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (10958650..10959885, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.
Title: Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.
targets cancer stem cells by suppressing cancer stemness characteristics and neuroblastoma cell invasion
Title: Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.
Human bitter taste receptors hTAS2R8 and hTAS2R39 display differential functions to recognize bitter peptides.
Title: Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TAS2R8__5214 (e-PCR)
- UniSTS:464591

NoName (e-PCR)
- UniSTS:481009

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables taste receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 8

Names: taste receptor, family B, member 5; taste receptor, type 2, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023918.3 → NP_076407.1 taste receptor type 2 member 8

See identical proteins and their annotated locations for NP_076407.1

Status: REVIEWED

Source sequence(s)

AC006518

Consensus CDS

CCDS8632.1

UniProtKB/Swiss-Prot

Q4KN29, Q645Y2, Q9NYW2

UniProtKB/TrEMBL

Q4KN04

Related

ENSP00000240615.2, ENST00000240615.3

Conserved Domains (1) summary

cd15022
Location:7 → 298

7tm_TAS2R8; mammalian taste receptor 2, subtype 8, member of the seven-transmembrane G protein-coupled receptor superfamily