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Hpcal4 hippocalcin-like 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50872, updated on 5-Mar-2024

Summary

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Official Symbol
Hpcal4provided by RGD
Official Full Name
hippocalcin-like 4provided by RGD
Primary source
RGD:708491
See related
Ensembl:ENSRNOG00000050983 AllianceGenome:RGD:708491
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NVP-2; Nvjp2
Summary
Enables calcium channel regulator activity; protein C-terminus binding activity; and protein domain specific binding activity. Predicted to be involved in signal transduction. Orthologous to human HPCAL4 (hippocalcin like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 332.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140739577..140751529)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135454477..135466417)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140870127..140882242)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 8b Neighboring gene peptidylprolyl isomerase E Neighboring gene uncharacterized LOC134486987 Neighboring gene uncharacterized LOC120102973 Neighboring gene 5'-nucleotidase, cytosolic IA Neighboring gene uncharacterized LOC108351027 Neighboring gene hes-related family bHLH transcription factor with YRPW motif-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of two additional members of the neural visinin-like Ca(2+)-binding protein gene family. Kajimoto Y, et al. J Neurochem, 1993 Sep. PMID 8360675
  2. Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. Okazaki K, et al. Biochem Biophys Res Commun, 1992 May 29. PMID 1599450
  3. Differential regulation of CaV2.1 channels by calcium-binding protein 1 and visinin-like protein-2 requires N-terminal myristoylation. Few AP, et al. J Neurosci, 2005 Jul 27. PMID 16049184, Free PMC Article
  4. cDNA cloning of a neural visinin-like Ca(2+)-binding protein. Kuno T, et al. Biochem Biophys Res Commun, 1992 May 15. PMID 1375457
  5. Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus. Kobayashi M, et al. Biochem Biophys Res Commun, 1992 Nov 30. PMID 1280427

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
hippocalcin-like protein 4
Names
NVL-2
VILIP-2
neural visinin-like Ca2+-binding protein type 2
neural visinin-like protein 2
visinin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017357.1 → NP_059053.1  hippocalcin-like protein 4

    See identical proteins and their annotated locations for NP_059053.1

    Status: PROVISIONAL

    Source sequence(s)
    D13125
    UniProtKB/Swiss-Prot
    P35332
    UniProtKB/TrEMBL
    A6IS20
    Conserved Domains (1) summary
    COG5126
    Location:13 → 181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    140739577..140751529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238829.5 → XP_006238891.1  hippocalcin-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006238891.1

    UniProtKB/Swiss-Prot
    P35332
    UniProtKB/TrEMBL
    A6IS20
    Related
    ENSRNOP00000066655.1
    Conserved Domains (1) summary
    COG5126
    Location:13 → 181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35332.2 GenPept UniProtKB/Swiss-Prot:P35332

Gene LinkOut

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