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Il27ra interleukin 27 receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 50931, updated on 21-Sep-2021

Summary

Official Symbol
Il27raprovided by MGI
Official Full Name
interleukin 27 receptor, alphaprovided by MGI
Primary source
MGI:MGI:1355318
See related
Ensembl:ENSMUSG00000005465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-; Tcc; CRL1; Tccr; WSX-; Wsx1; WSX-1; IL-27R; zcytor1
Expression
Biased expression in spleen adult (RPKM 26.4), thymus adult (RPKM 23.9) and 8 other tissues See more
Orthologs
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Genomic context

See Il27ra in Genome Data Viewer
Location:
8; 8 C2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84756915..84769250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84030286..84042600, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (86554185..86566474, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 1199 Neighboring gene MISP family member 3 Neighboring gene paralemmin 3 Neighboring gene predicted gene, 53445 Neighboring gene relaxin 3 Neighboring gene regulatory factor X, 1 (influences HLA class II expression) Neighboring gene microRNA 709

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-12 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-23 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-27 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-27 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell extravasation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of T-helper 17 type immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cellular extravasation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of interleukin-17 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of activated T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of interleukin-12 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of interleukin-23 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-27 receptor subunit alpha
Names
IL-27 receptor subunit alpha
IL-27R subunit alpha
IL-27R-alpha
IL-27RA
T cell cytokine receptor
T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
cytokine receptor family, class 1 (WSXWS), member 1
type I T-cell cytokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016671.3NP_057880.2  interleukin-27 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_057880.2

    Status: VALIDATED

    Source sequence(s)
    AK133753, BC032878, BF019826
    Consensus CDS
    CCDS22465.1
    UniProtKB/Swiss-Prot
    O70394
    UniProtKB/TrEMBL
    Q3UZN3
    Related
    ENSMUSP00000005601.8, ENSMUST00000005601.9
    Conserved Domains (1) summary
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84756915..84769250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243668.2XP_030099528.1  interleukin-27 receptor subunit alpha isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:315394
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_036154161.1XP_036010054.1  interleukin-27 receptor subunit alpha isoform X3

    Conserved Domains (1) summary
    cl21522
    Location:93172
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_011248437.3XP_011246739.1  interleukin-27 receptor subunit alpha isoform X2

    Conserved Domains (2) summary
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:315394
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_036154162.1XP_036010055.1  interleukin-27 receptor subunit alpha isoform X4

    Conserved Domains (1) summary
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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