Slc7a8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc7a8provided by MGI
Official Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8provided by MGI
Primary source: MGI:MGI:1355323
See related: Ensembl:ENSMUSG00000022180 AllianceGenome:MGI:1355323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAT2
Summary: Enables glycine transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Involved in amino acid transport and thyroid hormone transport. Acts upstream of or within L-amino acid transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study sensorineural hearing loss. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 137.5), duodenum adult (RPKM 56.6) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.91 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54959672..55019343, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54722215..54781886, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy.
Title: Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy.
Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion.
Title: Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion.
Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance.
Title: Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance.
distinct molecular LAT2-features determine bidirectional amino acid transport but only an unidirectional thyroid hormone import.
Title: Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids.
Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive genes remained unchanged in Slc7a8(-/-) mice, possibly because of functional compensation by the thyroid hormone transporter Mct8, which is co-expressed in many cell types
Title: Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8.
LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP mRNAs were not.
Title: The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells.
The positive effect of non-T cell activation linker (NTAL) on Akt phosphorylation and mast cell survival requires LAT.
Title: Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells.
System L functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids.
Title: Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells.
the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates
Title: Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger.
In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.
Title: Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124773 (e-PCR)
- UniSTS:161595

C86595 (e-PCR)
- UniSTS:209032

Slc7a8 (e-PCR), detects polymorphism
- UniSTS:496016

Lat2 (e-PCR), detects polymorphism
- UniSTS:526751

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amine transmembrane transporter activity	ISA Inferred from Sequence Alignment more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables glycine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables thyroid hormone transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-leucine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amino acid transport	ISA Inferred from Sequence Alignment more info	PubMed
involved_in amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in glycine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in proline transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid hormone transport	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid hormone transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tryptophan transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large neutral amino acids transporter small subunit 2

Names: L-type amino acid transporter 2; mLAT2; solute carrier family 7 member 8; solute carrier family 8 (cationic amino acid transporter, y+ system), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016972.2 → NP_058668.1 large neutral amino acids transporter small subunit 2

See identical proteins and their annotated locations for NP_058668.1

Status: PROVISIONAL

Source sequence(s)

BC059004

Consensus CDS

CCDS27101.1

UniProtKB/Swiss-Prot

Q9QXW9

Related

ENSMUSP00000022787.7, ENSMUST00000022787.8

Conserved Domains (1) summary

TIGR00911
Location:1 → 497

2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

54959672..55019343 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519250.4 → XP_006519313.1 large neutral amino acids transporter small subunit 2 isoform X1

Conserved Domains (1) summary

TIGR00911
Location:1 → 295

2A0308; L-type amino acid transporter
XM_011245114.1 → XP_011243416.1 large neutral amino acids transporter small subunit 2 isoform X2

Conserved Domains (1) summary

TIGR00911
Location:39 → 274

2A0308; L-type amino acid transporter