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CDON cell adhesion associated, oncogene regulated [ Homo sapiens (human) ]

Gene ID: 50937, updated on 5-Mar-2024

Summary

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Official Symbol
CDONprovided by HGNC
Official Full Name
cell adhesion associated, oncogene regulatedprovided by HGNC
Primary source
HGNC:HGNC:17104
See related
Ensembl:ENSG00000064309 MIM:608707; AllianceGenome:HGNC:17104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDO; Ihog; CDON1; HPE11; ORCAM
Summary
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
Expression
Broad expression in thyroid (RPKM 12.5), ovary (RPKM 11.8) and 17 other tissues See more
Orthologs
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Genomic context

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See CDON in Genome Data Viewer
Location:
11q24.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125956821..126063352, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125985675..126092163, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125826716..125933187, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125802853-125803806 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:125805158-125805722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4045 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene VISTA enhancer hs1641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4047 Neighboring gene NANOG hESC enhancer GRCh37_chr11:125946539-125947040 Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 1 Neighboring gene uncharacterized LOC124902782 Neighboring gene uncharacterized LOC107984407

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Nonsense Mutation in the Hedgehog Receptor CDON Associated With Pituitary Stalk Interruption Syndrome. Bashamboo A, et al. J Clin Endocrinol Metab, 2016 Jan. PMID 26529631
  2. CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. Leem YE, et al. PLoS One, 2014. PMID 25369201, Free PMC Article
  3. Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication. Sanchez-Arrones L, et al. Int J Biochem Cell Biol, 2012 May. PMID 22326621
  4. Identification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of CDON is involved in tumor cell growth and invasion. Hayashi T, et al. Pathobiology, 2011. PMID 21849809
  5. Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis. Ahn BY, et al. Exp Mol Med, 2023 Jan. PMID 36609601, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis.
    Title: Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis.
  2. Exome sequencing in patients with microphthalmia, anophthalmia, and coloboma (MAC) from a consanguineous population.
    Title: Exome sequencing in patients with microphthalmia, anophthalmia, and coloboma (MAC) from a consanguineous population.
  3. Compound heterozygous splicing CDON variants result in isolated ocular coloboma.
    Title: Compound heterozygous splicing CDON variants result in isolated ocular coloboma.
  4. We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
    Title: A Nonsense Mutation in the Hedgehog Receptor CDON Associated With Pituitary Stalk Interruption Syndrome.
  5. CDO is required for proliferation and survival of lung cancer cells via Hh signaling.
    Title: CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling.
  6. These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
    Title: Regulation by miR181 family of the dependence receptor CDON tumor suppressive activity in neuroblastoma.
  7. Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
    Title: Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer.
  8. Mutations in the CDON cause holoprosencephaly. (Review)
    Title: Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication.
  9. We found that CDON is overexpressed in prostate cancer
    Title: Identification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of CDON is involved in tumor cell growth and invasion.
  10. CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
    Title: Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Holoprosencephaly 11
MedGen: C3280215 OMIM: 614226 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog
Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
EBI GWAS Catalog
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic body morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in lens development in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in myoblast fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal muscle satellite cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cell adhesion molecule-related/down-regulated by oncogenes
Names
Cdon homolog
surface glycoprotein, Ig superfamily member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029776.1 RefSeqGene

    Range
    5001..111475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243597.2 → NP_001230526.1  cell adhesion molecule-related/down-regulated by oncogenes isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB209396, AP000842, BC098583, BC112362
    Consensus CDS
    CCDS58192.1
    UniProtKB/Swiss-Prot
    O14631, Q4KMG0
    Related
    ENSP00000376458.3, ENST00000392693.7
    Conserved Domains (6) summary
    cd00096
    Location:422 → 514
    Ig; Immunoglobulin domain
    smart00408
    Location:326 → 387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 397
    IG_like; Immunoglobulin like
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405 → 517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

  2. NM_001378964.1 → NP_001365893.1  cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000821, AP000842
    Consensus CDS
    CCDS8468.1
    Related
    ENSP00000432901.2, ENST00000531738.6
    Conserved Domains (6) summary
    smart00408
    Location:237 → 297
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:590 → 666
    fn3; Fibronectin type III domain
    pfam07679
    Location:313 → 387
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:141 → 200
    Ig; Immunoglobulin domain
    cl11960
    Location:29 → 114
    Ig; Immunoglobulin domain

  3. NM_016952.5 → NP_058648.4  cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor

    See identical proteins and their annotated locations for NP_058648.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF004841, AI190027, AP000842, BC112362
    Consensus CDS
    CCDS8468.1
    UniProtKB/Swiss-Prot
    Q4KMG0
    Related
    ENSP00000263577.7, ENST00000263577.11
    Conserved Domains (6) summary
    smart00408
    Location:237 → 297
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:590 → 666
    fn3; Fibronectin type III domain
    pfam07679
    Location:313 → 387
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:141 → 200
    Ig; Immunoglobulin domain
    cl11960
    Location:29 → 114
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    125956821..126063352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427064.1 → XP_047283020.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  2. XM_017017873.2 → XP_016873362.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    UniProtKB/Swiss-Prot
    O14631, Q4KMG0
    Related
    ENSP00000507318.1, ENST00000684078.1
    Conserved Domains (6) summary
    cd00096
    Location:422 → 514
    Ig; Immunoglobulin domain
    smart00408
    Location:326 → 387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 397
    IG_like; Immunoglobulin like
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405 → 517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

  3. XM_047427062.1 → XP_047283018.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  4. XM_011542864.3 → XP_011541166.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541166.1

    UniProtKB/Swiss-Prot
    O14631, Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422 → 514
    Ig; Immunoglobulin domain
    smart00408
    Location:326 → 387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 397
    IG_like; Immunoglobulin like
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405 → 517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

  5. XM_011542862.4 → XP_011541164.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541164.1

    UniProtKB/Swiss-Prot
    O14631, Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422 → 514
    Ig; Immunoglobulin domain
    smart00408
    Location:326 → 387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 397
    IG_like; Immunoglobulin like
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405 → 517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

  6. XM_047427063.1 → XP_047283019.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  7. XM_011542865.3 → XP_011541167.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541167.1

    UniProtKB/Swiss-Prot
    O14631, Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422 → 514
    Ig; Immunoglobulin domain
    smart00408
    Location:326 → 387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 397
    IG_like; Immunoglobulin like
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405 → 517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

  8. XM_047427061.1 → XP_047283017.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  9. XM_011542863.3 → XP_011541165.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541165.1

    UniProtKB/Swiss-Prot
    O14631, Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422 → 514
    Ig; Immunoglobulin domain
    smart00408
    Location:326 → 387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 397
    IG_like; Immunoglobulin like
    cd00063
    Location:721 → 811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405 → 517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

  10. XM_047427060.1 → XP_047283016.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    UniProtKB/Swiss-Prot
    O14631, Q4KMG0

  11. XM_047427065.1 → XP_047283021.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

    UniProtKB/TrEMBL
    A0A804HL16
    Related
    ENSP00000508160.1, ENST00000684636.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    125985675..126092163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369042.1 → XP_054225017.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  2. XM_054369038.1 → XP_054225013.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

  3. XM_054369041.1 → XP_054225016.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  4. XM_054369035.1 → XP_054225010.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

  5. XM_054369034.1 → XP_054225009.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

  6. XM_054369040.1 → XP_054225015.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  7. XM_054369037.1 → XP_054225012.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

  8. XM_054369033.1 → XP_054225008.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

  9. XM_054369036.1 → XP_054225011.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

  10. XM_054369039.1 → XP_054225014.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

  11. XM_054369043.1 → XP_054225018.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KMG0.2 GenPept UniProtKB/Swiss-Prot:Q4KMG0

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