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SLC35B3 solute carrier family 35 member B3 [ Homo sapiens (human) ]

Gene ID: 51000, updated on 11-Apr-2024

Summary

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Official Symbol
SLC35B3provided by HGNC
Official Full Name
solute carrier family 35 member B3provided by HGNC
Primary source
HGNC:HGNC:21601
See related
Ensembl:ENSG00000124786 MIM:610845; AllianceGenome:HGNC:21601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-19; PAPST2; C6orf196
Summary
This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in colon (RPKM 11.6), thyroid (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p24.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (8411435..8435567, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (8280719..8304851, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (8411668..8435800, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374910 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:8180101-8180646 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:8230067-8230588 Neighboring gene uncharacterized LOC105374911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96039 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:8383593-8384467 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:8387849-8389048 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96052 Neighboring gene MPRA-validated peak5649 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96058 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96067 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96069 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96073 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96077 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23962 Neighboring gene uncharacterized LOC100506207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:8435518-8436059 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96121 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96126 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96137 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96153 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96161 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96186 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96299 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96383 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96450 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96469 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:8619731-8620403 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:8627414-8628613 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96605 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96748 Neighboring gene hepatocellular carcinoma up-regulated long non-coding RNA Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96779 Neighboring gene uncharacterized LOC112267952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3]. Li D, et al. Zhonghua Yi Xue Za Zhi, 2010 Nov 30. PMID 21211351
  2. Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. Goren A, et al. Mol Cell, 2006 Jun 23. PMID 16793546
  3. Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2. Kamiyama S, et al. J Biol Chem, 2006 Apr 21. PMID 16492677
  4. Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. Kamiyama S, et al. Glycobiology, 2011 Feb. PMID 20978009
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The specifically up-regulated non-coding gene HULC in HepG2 cell line has some effects on the expression of its neighboring gene SLC35B3.
    Title: [Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3].
  2. PAPS transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status.
    Title: Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma.
  3. PAPST2 is a PAPS transporter gene involved in the synthesis of sulfated glycoconjugates in the colon
    Title: Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5'-adenylyl sulfate transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosine 3'-phospho 5'-phosphosulfate transporter 2
Names
3' phosphoadenosine 5' phosphosulfate transporter 2
PAPS transporter 2
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142540.2 → NP_001136012.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL355815, BC006973, BX647208, DC357624
    UniProtKB/Swiss-Prot
    A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:80 → 371
    UAA; UAA transporter family

  2. NM_001142541.3 → NP_001136013.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_001136013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK313522, AL355815, BC006973, BX538271, DB188586, DB576665
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:80 → 371
    UAA; UAA transporter family

  3. NM_001370476.2 → NP_001357405.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL355815
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    B2R8V5
    Related
    ENSP00000496368.1, ENST00000644923.2
    Conserved Domains (1) summary
    pfam08449
    Location:80 → 371
    UAA; UAA transporter family

  4. NM_001370477.1 → NP_001357406.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL355815
    UniProtKB/TrEMBL
    B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:48 → 308
    UAA; UAA transporter family

  5. NM_001370478.2 → NP_001357407.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 3.
    Source sequence(s)
    AL355815
    Consensus CDS
    CCDS93854.1
    UniProtKB/TrEMBL
    A0A024QZW4, B2R8V5
    Related
    ENSP00000498054.1, ENST00000648987.1
    Conserved Domains (1) summary
    pfam08449
    Location:48 → 339
    UAA; UAA transporter family

  6. NM_001370479.2 → NP_001357408.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 3.
    Source sequence(s)
    AL355815
    Consensus CDS
    CCDS93854.1
    UniProtKB/TrEMBL
    A0A024QZW4, B2R8V5
    Related
    ENSP00000518269.1, ENST00000710437.1
    Conserved Domains (1) summary
    pfam08449
    Location:48 → 339
    UAA; UAA transporter family

  7. NM_015948.5 → NP_057032.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_057032.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK303940, AL355815, BC006973, BX538271, DB188586, DB576665
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    B2R8V5
    Related
    ENSP00000368981.4, ENST00000379660.4
    Conserved Domains (1) summary
    pfam08449
    Location:80 → 371
    UAA; UAA transporter family

RNA

  1. NR_109913.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK303940, AK313522, AL355815, BX538271, DB188586, DB576665

  2. NR_109914.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL355815, BX647208, DB188586, DB576665

  3. NR_163441.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355815
    Related
    ENST00000648867.1

  4. NR_163442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355815

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    8411435..8435567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010912.3 → XP_016866401.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

    UniProtKB/TrEMBL
    B2R8V5

  2. XM_011514648.2 → XP_011512950.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    See identical proteins and their annotated locations for XP_011512950.1

    UniProtKB/TrEMBL
    A0A024QZW4, B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:48 → 339
    UAA; UAA transporter family

  3. XM_047418848.1 → XP_047274804.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X9

  4. XM_047418842.1 → XP_047274798.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  5. XM_047418844.1 → XP_047274800.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  6. XM_006715103.4 → XP_006715166.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4

    UniProtKB/TrEMBL
    B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:82 → 342
    UAA; UAA transporter family

  7. XM_047418845.1 → XP_047274801.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  8. XM_047418841.1 → XP_047274797.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X2

  9. XM_047418840.1 → XP_047274796.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1

  10. XM_017010913.2 → XP_016866402.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

    UniProtKB/TrEMBL
    B2R8V5

  11. XM_017010910.2 → XP_016866399.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:80 → 371
    UAA; UAA transporter family

  12. XM_017010911.2 → XP_016866400.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:80 → 371
    UAA; UAA transporter family

  13. XM_047418843.1 → XP_047274799.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  14. XM_047418846.1 → XP_047274802.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X7

  15. XM_047418847.1 → XP_047274803.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X8

  16. XM_047418849.1 → XP_047274805.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X10

RNA

  1. XR_007059268.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    8280719..8304851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355541.1 → XP_054211516.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

  2. XM_054355544.1 → XP_054211519.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  3. XM_054355543.1 → XP_054211518.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  4. XM_054355549.1 → XP_054211524.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X9

  5. XM_054355542.1 → XP_054211517.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  6. XM_054355546.1 → XP_054211521.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  7. XM_054355539.1 → XP_054211514.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4

  8. XM_054355545.1 → XP_054211520.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4

  9. XM_054355537.1 → XP_054211512.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X2

  10. XM_054355536.1 → XP_054211511.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1

  11. XM_054355540.1 → XP_054211515.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

  12. XM_054355538.1 → XP_054211513.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308

  13. XM_054355547.1 → XP_054211522.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X7

  14. XM_054355548.1 → XP_054211523.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X8

  15. XM_054355550.1 → XP_054211525.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X10

RNA

  1. XR_008487337.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H1N7.1 GenPept UniProtKB/Swiss-Prot:Q9H1N7

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