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RRP15 ribosomal RNA processing 15 homolog [ Homo sapiens (human) ]

Gene ID: 51018, updated on 3-Apr-2024

Summary

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Official Symbol
RRP15provided by HGNC
Official Full Name
ribosomal RNA processing 15 homologprovided by HGNC
Primary source
HGNC:HGNC:24255
See related
Ensembl:ENSG00000067533 MIM:611193; AllianceGenome:HGNC:24255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-115; KIAA0507
Summary
This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 2.4), fat (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

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See RRP15 in Genome Data Viewer
Location:
1q41
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (218285293..218337983)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (217520058..217572747)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (218458635..218511325)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 141, pseudogene Neighboring gene uncharacterized LOC105372923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1819 Neighboring gene ribosomal protein S26 pseudogene 17 Neighboring gene TGFB2 antisense RNA 1 (head to head) Neighboring gene transforming growth factor beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression. Dong Z, et al. Cell Death Dis, 2023 Feb 7. PMID 36750557, Free PMC Article
  2. Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis. Zhao D, et al. Cancer Lett, 2021 Oct 28. PMID 34343634
  3. The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells. Dong Z, et al. Oncotarget, 2017 Feb 21. PMID 28099941, Free PMC Article
  4. Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer. Deng Z, et al. Int J Mol Sci, 2023 Feb 9. PMID 36834940, Free PMC Article
  5. Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. De Marchis ML, et al. RNA, 2005 Apr. PMID 15769876, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer.
    Title: Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer.
  2. RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated beta-catenin suppression.
    Title: RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression.
  3. Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis.
    Title: Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis.
  4. Data suggest that ribosomal RNA-processing protein 15 (RRP15) might be a potential target for cancer therapy.
    Title: The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells.
  5. The budding yeast homolog of human RRP15 is required for maturation of 60S ribosomal particles
    Title: Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0507, MGC22291

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RRP15-like protein
Names
ribosomal RNA-processing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016052.4 → NP_057136.2  RRP15-like protein

    See identical proteins and their annotated locations for NP_057136.2

    Status: REVIEWED

    Source sequence(s)
    AC096638, AW029169, BC020641, BF242786
    Consensus CDS
    CCDS1520.2
    UniProtKB/Swiss-Prot
    Q9Y3B9
    UniProtKB/TrEMBL
    A8K201
    Related
    ENSP00000355899.3, ENST00000366932.4
    Conserved Domains (1) summary
    pfam07890
    Location:102 → 215
    Rrp15p; Rrp15p

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    218285293..218337983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421798.1 → XP_047277754.1  RRP15-like protein isoform X3

  2. XM_047421797.1 → XP_047277753.1  RRP15-like protein isoform X1

  3. XM_011509597.4 → XP_011507899.1  RRP15-like protein isoform X2

    Conserved Domains (1) summary
    pfam07890
    Location:102 → 215
    Rrp15p; Rrp15p

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    217520058..217572747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336842.1 → XP_054192817.1  RRP15-like protein isoform X3

  2. XM_054336840.1 → XP_054192815.1  RRP15-like protein isoform X1

  3. XM_054336841.1 → XP_054192816.1  RRP15-like protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y3B9.2 GenPept UniProtKB/Swiss-Prot:Q9Y3B9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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