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GLOD4 glyoxalase domain containing 4 [ Homo sapiens (human) ]

Gene ID: 51031, updated on 3-Apr-2024

Summary

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Official Symbol
GLOD4provided by HGNC
Official Full Name
glyoxalase domain containing 4provided by HGNC
Primary source
HGNC:HGNC:14111
See related
Ensembl:ENSG00000167699 MIM:620650; AllianceGenome:HGNC:14111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HC6; HC71; CGI-150; C17orf25
Summary
Enables cadherin binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 28.9), duodenum (RPKM 28.6) and 25 other tissues See more
Orthologs
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Genomic context

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See GLOD4 in Genome Data Viewer
Location:
17p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (759330..785895, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (644616..672323, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (662570..685520, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7945 Neighboring gene TLC domain containing 3A Neighboring gene gem nuclear organelle associated protein 4 Neighboring gene diazepam binding inhibitor-like 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11440 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:685572-686120 Neighboring gene Sharpr-MPRA regulatory region 8532 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11442 Neighboring gene nucleoredoxin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:736782-737522 Neighboring gene Sharpr-MPRA regulatory region 9814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:746053-747038 Neighboring gene uncharacterized LOC124903894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:753668-754242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:754898-755398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:773909-774736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:790499-790998 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:800010-801209 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:801761-802401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:802905-803406 Neighboring gene uncharacterized LOC101927727 Neighboring gene Sharpr-MPRA regulatory region 13189

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The promoter analysis of the human C17orf25 gene, a novel chromosome 17p13.3 gene. Guo JY, et al. Cell Res, 2002 Dec. PMID 12528892
  2. Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. Zhang HT, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Aug. PMID 12897971
  3. Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma. Qin WX, et al. Cell Res, 2001 Sep. PMID 11642406
  4. Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. Cardoso C, et al. Am J Hum Genet, 2003 Apr. PMID 12621583, Free PMC Article
  5. DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. Ahmed SF, et al. Sci Adv, 2020 Aug. PMID 32937373, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glyoxalase domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366247.2 → NP_001353176.1  glyoxalase domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Consensus CDS
    CCDS92216.1
    UniProtKB/Swiss-Prot
    D3DTG9, D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9HC38, Q9NVN1
    UniProtKB/TrEMBL
    A8K8F0
    Related
    ENSP00000301328.5, ENST00000301328.9
    Conserved Domains (2) summary
    cd16357
    Location:155 → 270
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:4 → 145
    VOC; vicinal oxygen chelate (VOC) family

  2. NM_001366248.2 → NP_001353177.1  glyoxalase domain-containing protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0, B3KV49
    Conserved Domains (2) summary
    cd16357
    Location:84 → 199
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:1 → 74
    VOC; vicinal oxygen chelate (VOC) family

  3. NM_001366249.2 → NP_001353178.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0, B7Z403
    Conserved Domains (2) summary
    cd16357
    Location:131 → 246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39 → 121
    VOC; vicinal oxygen chelate (VOC) family

  4. NM_001366250.2 → NP_001353179.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0, B7Z403
    Conserved Domains (2) summary
    cd16357
    Location:131 → 246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39 → 121
    VOC; vicinal oxygen chelate (VOC) family

  5. NM_001389725.1 → NP_001376654.1  glyoxalase domain-containing protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087392
    Conserved Domains (2) summary
    cd16357
    Location:206 → 321
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:4 → 196
    VOC; vicinal oxygen chelate (VOC) family

  6. NM_001389726.1 → NP_001376655.1  glyoxalase domain-containing protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0
    Conserved Domains (2) summary
    cd16357
    Location:177 → 292
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:4 → 167
    VOC; vicinal oxygen chelate (VOC) family

  7. NM_001389727.1 → NP_001376656.1  glyoxalase domain-containing protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140 → 255
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

  8. NM_001389728.1 → NP_001376657.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0, B7Z403
    Conserved Domains (2) summary
    cd16357
    Location:131 → 246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39 → 121
    VOC; vicinal oxygen chelate (VOC) family

  9. NM_001389729.1 → NP_001376658.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0, B7Z403
    Conserved Domains (2) summary
    cd16357
    Location:131 → 246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39 → 121
    VOC; vicinal oxygen chelate (VOC) family

  10. NM_001389730.1 → NP_001376659.1  glyoxalase domain-containing protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0, B7Z403
    Conserved Domains (2) summary
    cd16357
    Location:131 → 246
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:39 → 121
    VOC; vicinal oxygen chelate (VOC) family

  11. NM_001389731.1 → NP_001376660.1  glyoxalase domain-containing protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140 → 242
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

  12. NM_001389732.1 → NP_001376661.1  glyoxalase domain-containing protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140 → 248
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

  13. NM_001389733.1 → NP_001376662.1  glyoxalase domain-containing protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140 → 236
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

  14. NM_001389734.1 → NP_001376663.1  glyoxalase domain-containing protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    A8K8F0
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140 → 226
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

  15. NM_001389735.1 → NP_001376664.1  glyoxalase domain-containing protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    I3L3Q4
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:140 → 217
    VOC; vicinal oxygen chelate (VOC) family

  16. NM_001389736.1 → NP_001376665.1  glyoxalase domain-containing protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC087392
    UniProtKB/TrEMBL
    I3L3Q4
    Related
    ENSP00000460634.1, ENST00000576419.1
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:140 → 210
    VOC; vicinal oxygen chelate (VOC) family

  17. NM_016080.4 → NP_057164.3  glyoxalase domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_057164.3

    Status: VALIDATED

    Source sequence(s)
    AF061730, BC008605, DA608953
    Consensus CDS
    CCDS32520.1
    UniProtKB/TrEMBL
    A8K8F0
    Related
    ENSP00000301329.6, ENST00000301329.11
    Conserved Domains (2) summary
    cd08358
    Location:4 → 130
    GLOD4_N; N-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cd16357
    Location:140 → 255
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    759330..785895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436196.1 → XP_047292152.1  glyoxalase domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    B3KV49

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    644616..672323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316341.1 → XP_054172316.1  glyoxalase domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    B3KV49
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HC38.1 GenPept UniProtKB/Swiss-Prot:Q9HC38

Gene LinkOut

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