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DERA deoxyribose-phosphate aldolase [ Homo sapiens (human) ]

Gene ID: 51071, updated on 8-Jul-2021

Summary

Official Symbol
DERAprovided by HGNC
Official Full Name
deoxyribose-phosphate aldolaseprovided by HGNC
Primary source
HGNC:HGNC:24269
See related
Ensembl:ENSG00000023697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEOC; CGI-26
Expression
Ubiquitous expression in small intestine (RPKM 26.2), kidney (RPKM 24.6) and 25 other tissues See more
Orthologs
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Genomic context

See DERA in Genome Data Viewer
Location:
12p12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (15911332..16037381)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (16064266..16190315)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724146 Neighboring gene mitochondrial ribosomal protein S7 pseudogene 2 Neighboring gene serine/threonine kinase receptor associated protein Neighboring gene egl-9 family hypoxia-inducible factor 3 pseudogene 1 Neighboring gene VISTA enhancer hs798 Neighboring gene uncharacterized LOC101928362 Neighboring gene solute carrier family 15 member 5 Neighboring gene microsomal glutathione S-transferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables deoxyribose-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxyribose-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deoxyribose-phosphate aldolase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in deoxyribonucleoside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in deoxyribonucleotide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in deoxyribose phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
deoxyribose-phosphate aldolase
Names
2-deoxy-D-ribose 5-phosphate aldolase
2-deoxyribose-5-phosphate aldolase homolog
deoxyriboaldolase
deoxyribose-phosphate aldolase (putative)
phosphodeoxyriboaldolase
putative deoxyribose-phosphate aldolase
NP_001287708.1
NP_057038.2
XP_024304768.1
XP_024304769.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300779.2NP_001287708.1  deoxyribose-phosphate aldolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC022073, BC041328, BU928832, CB851336
    Consensus CDS
    CCDS73451.1
    UniProtKB/TrEMBL
    E9PPM8
    Related
    ENSP00000436999.1, ENST00000532964.5
    Conserved Domains (1) summary
    cl21457
    Location:50234
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
  2. NM_015954.4NP_057038.2  deoxyribose-phosphate aldolase isoform 1

    See identical proteins and their annotated locations for NP_057038.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC041328, CB851336
    Consensus CDS
    CCDS44838.1
    UniProtKB/Swiss-Prot
    Q9Y315
    Related
    ENSP00000416583.2, ENST00000428559.7
    Conserved Domains (1) summary
    cd00959
    Location:50277
    DeoC; 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    15911332..16037381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449001.1XP_024304769.1  deoxyribose-phosphate aldolase isoform X1

    Conserved Domains (1) summary
    cd00959
    Location:8189
    DeoC; 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family
  2. XM_024449000.1XP_024304768.1  deoxyribose-phosphate aldolase isoform X1

    Related
    ENSP00000431757.1, ENST00000526530.1
    Conserved Domains (1) summary
    cd00959
    Location:8189
    DeoC; 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family
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