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ELOA2 elongin A2 [ Homo sapiens (human) ]

Gene ID: 51224, updated on 5-Mar-2024

Summary

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Official Symbol
ELOA2provided by HGNC
Official Full Name
elongin A2provided by HGNC
Primary source
HGNC:HGNC:30771
See related
Ensembl:ENSG00000206181 MIM:609522; AllianceGenome:HGNC:30771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT832; TCEB3B; TCEB3L
Summary
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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Location:
18q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (47032527..47035621, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (47222798..47225892, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44558898..44561992, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44546997-44547496 Neighboring gene elongin A3 family member D, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44552405-44553168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44553169-44553932 Neighboring gene MPRA-validated peak3137 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44554945-44555448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44555449-44555951 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:44555952-44556454 Neighboring gene elongin A3 family member B, pseudogene Neighboring gene uncharacterized LOC105372098 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:44626710-44626922 Neighboring gene haloacid dehalogenase like hydrolase domain containing 2 Neighboring gene small ubiquitin-related modifier 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. Aso T, et al. J Biol Chem, 2000 Mar 3. PMID 10692460
  2. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Aso T, et al. Science, 1995 Sep 8. PMID 7660129
  3. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. Bradsher JN, et al. J Biol Chem, 1993 Dec 5. PMID 8244996
  4. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Anders L, et al. Cancer Cell, 2011 Nov 15. PMID 22094256, Free PMC Article
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. Lu L, et al. J Biol Chem, 2013 Dec 13. PMID 24163370, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC119351

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription elongation TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of elongin complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
elongin-A2
Names
RNA polymerase II transcription factor SIII subunit A2
transcription elongation factor (SIII) elongin A2 elongin A2
transcription elongation factor B polypeptide 3B
transcription elongation factor B subunit 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050760.1 RefSeqGene

    Range
    4997..8091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016427.3 → NP_057511.2  elongin-A2

    See identical proteins and their annotated locations for NP_057511.2

    Status: REVIEWED

    Source sequence(s)
    AB030834, AC012254, BC036022
    Consensus CDS
    CCDS11932.1
    UniProtKB/Swiss-Prot
    Q8IYF1, Q9P2V9
    UniProtKB/TrEMBL
    B2RC86
    Related
    ENSP00000331302.4, ENST00000332567.6
    Conserved Domains (2) summary
    smart00509
    Location:8 → 77
    TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
    pfam06881
    Location:544 → 642
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    47032527..47035621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    47222798..47225892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYF1.2 GenPept UniProtKB/Swiss-Prot:Q8IYF1

Gene LinkOut

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