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DLAT dihydrolipoamide S-acetyltransferase [ Bos taurus (cattle) ]

Gene ID: 512723, updated on 4-Apr-2024

Summary

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Official Symbol
DLATprovided by VGNC
Official Full Name
dihydrolipoamide S-acetyltransferaseprovided by VGNC
Primary source
VGNC:VGNC:109392
See related
Ensembl:ENSBTAG00000010709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PDCE2; PDC-E2
Orthologs
human mouse all
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Genomic context

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See DLAT in Genome Data Viewer
Location:
chromosome: 15
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (22340056..22374925)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene chromosome 15 C11orf52 homolog Neighboring gene DIX domain containing 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like Neighboring gene HIG1 domain family member 1A, mitochondrial-like Neighboring gene PIH1 domain containing 2 Neighboring gene NKAP domain containing 1 Neighboring gene translocase of inner mitochondrial membrane 8 homolog B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequences directing dihydrolipoamide dehydrogenase (E3) binding are located on the 2-oxoglutarate dehydrogenase (E1) component of the mammalian 2-oxoglutarate dehydrogenase multienzyme complex. Rice JE, et al. EMBO J, 1992 Sep. PMID 1505515, Free PMC Article
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dihydrolipoyllysine-residue acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of pyruvate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Names
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Pyruvate dehydrogenase complex component E2
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
NP_001192659.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205730.2 → NP_001192659.2  dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

    See identical proteins and their annotated locations for NP_001192659.2

    Status: VALIDATED

    Source sequence(s)
    AW653048, DT900308, DV808203, DV912618, DY133435, EE252483, EV678857, EV678914
    UniProtKB/Swiss-Prot
    F1N690, P11180, V6F7T1
    Related
    ENSBTAP00000014176.5, ENSBTAT00000014176.6
    Conserved Domains (4) summary
    cd06849
    Location:219 → 293
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01349
    Location:221 → 647
    PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam00198
    Location:436 → 647
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    pfam02817
    Location:356 → 389
    E3_binding; e3 binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    22340056..22374925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11180.2 GenPept UniProtKB/Swiss-Prot:P11180

Gene LinkOut

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