PCYOX1 prenylcysteine oxidase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PCYOX1provided by HGNC
Official Full Name: prenylcysteine oxidase 1provided by HGNC
Primary source: HGNC:HGNC:20588
See related: Ensembl:ENSG00000116005 MIM:610995; AllianceGenome:HGNC:20588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PCL1
Summary: Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in fat (RPKM 61.1), kidney (RPKM 49.9) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p13.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (70257915..70281185)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (70269656..70292921)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (70485269..70508317)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis.
Title: Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis.
Prenylcysteine oxidase 1, an emerging player in atherosclerosis.
Title: Prenylcysteine oxidase 1, an emerging player in atherosclerosis.
Elevated prenylcysteine oxidase 1 (PCYOX1) activity could help to propagate the oxidative burden of low density lipoproteins (LDLs), thus making PCYOX1 a potential pharmacological target and a new biomarker in cardiovascular disease [Review].
Title: Prenylcysteine oxidase 1, a pro-oxidant enzyme of low density lipoproteins.
Addition of the substrate farnesylcysteine to lipoprotein resulted in a time-dependent generation of H(2)O(2) which was stronger in very low density lipoprotein (VLDL) than in LDL or HDL, reflecting the greater protein content of PCL1 in VLDL.
Title: Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme.
initial studies of the kinetic mechanism and stereospecificity of this unusual enzyme
Title: Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

SHGC-30019 (e-PCR)
- UniSTS:69132

sY3084 (e-PCR)
- UniSTS:515126

G31113 (e-PCR)
- UniSTS:82300

RH102832 (e-PCR)
- UniSTS:97166

D11S3114 (e-PCR)
- UniSTS:152207

PCYOX1__7050 (e-PCR)
- UniSTS:471707

RH47273 (e-PCR)
- UniSTS:27051

RH64952 (e-PCR)
- UniSTS:92101

RH98964 (e-PCR)
- UniSTS:88793

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables FAD binding	IDA Inferred from Direct Assay more info	PubMed
enables farnesylcysteine lyase activity	IEA Inferred from Electronic Annotation more info
enables prenylcysteine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prenylcysteine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in prenylated protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prenylated protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prenylated protein catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in prenylcysteine catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
part_of very-low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prenylcysteine oxidase 1

Names: prenylcysteine lyase

NP_057381.3

EC 1.8.3.5

XP_047300645.1

EC 1.8.3.5

XP_054198442.1

EC 1.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.